| Periodontitis | Heart Ischemia | ||||
|---|---|---|---|---|---|
| Gene Symbol | Gene Name | Role | Gene Symbol | Gene Name | Role |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | Increased activity beneath periodontal lesions | TP53 | tumor protein p53 | Induces apoptosis of cardiac myocytes |
| CBL | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | Triggering of inflammation | NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
Some polymorphisms are associated to heart dysfunction
Triggering of inflammation |
| GRB2 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | Marker of severe periodontitis | BCL2 | B-cell CLL/lymphoma 2 | Protection of myocytes from apoptosis |
| PIK3R1 | growth factor receptor-bound protein 2 | Possible involvement in growth and differentiation in periodontal tissues, via the EGFR/RAS signalling | MAPK3 | mitogen-activated protein kinase 3 | Protection of myocytes from apoptosis |
| RELA | Cas-Br-M (murine) ecotropic retroviral transforming sequence | Possible involvement in bone resorption | MAPK1 | mitogen-activated protein kinase 1 | Protection of myocytes from apoptosis |
| SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | Induces apoptosis of cardiac myocytes | |||