Fig. (2) HPLC chromatograms of Epo B incubated with human recombinant CYP3A and 2C. Panel A: comparison of chromatograms from incubations of Epo B with CYP2C and CYP3A. Panels B and C: 50µM Epo B was incubated for 24 hrs with cell lines expressing different CYP3A (panel B) or CYP2C (panel C). Culture medium were extracted with dichloromethane, processed as in Material and methods and monitored at 254 nm.