Table 1:
Inhibition of the Formation of Oxidative Epo B Metabolites by Various P450 Inhibitors
Metabolite 1
Metabolite 2
Metabolite 3
No inhibitor
100
100
100
2 µM ketoconazole
0
17
101
10 µM sulfaphenazole
93
88
100
5 µM furafylline
101
83
118
30 µM ticlopidine
133
80
54
The value indicated is the residual activity of oxidation of Epo B by a pool of human liver microsomes in the presence or not of specific inhibitors.