Table 2: Formation of Oxidative Epo B Metabolites by Recombinant CYP Proteins Expressed in Ad 293 Cells. Results are Expressed as Pmoles Metabolites Formed in 24hrs Per mg Protein. < : Lower than 10 Pmoles Formed in 24hrs Per mg Protein

Metabolite 1 Metabolite 2 Metabolite 3
Native Ad < <
CYP1A1 < < <
CYP1A2 12 75 <
CYP2A6 < 386 176
CYP2B6 < 206 <
CYP2C8 < < 153
CYP2C9 < < 1581
CYP2C18 < < 143
CYP2C19 < < 2888
CYP2D6 < < <
CYP2E1 < < <
CYP3A4 2634 4394 <
CYP3A5 < 950 <
CYP3A7 < 348 <