Table 3: Inhibition of Monooxygenase Activities by Epo B. IC₅₀ Values in this Table Indicate the Concentration of Epo B Producing 50%s Inhibition of Probe Substrate Metabolism

CYP	Probe Reaction	Probe Substrate Concentration (µM)	Epo B
			IC50 (M)	Ki (µM)
1A2	Phenacetin O-deethylation	5	> 100 µM
2C8	Paclitaxel 6α-hydroxylation	10	>100 µM
2C9	Diclofenac 4’-hydroxylation	5	~25 µM
2C19	S-Mephenytoin 4’-hydroxylation	15	~5 µM	1.75
2D6	Bufuralol 1’-hydroxylation	5	~75 µM
2E1	Chlorzoxazone 6-hydroxylation	10	> 100 µM
3A4/5	Midazolam 1’-hydroxylation	5	~5 µM	1.85
3A4/5	Testosterone 6β-hydroxylation	25	~5 µM