Fig. (6) Positions characterizing human CYP1A2 from the three other CYP1As. (A). View of the proximal side of the CYP1A2 protein with seven surface residues identified as implicated in steroid metabolism particularity coloured cyan; the heme is coloured pink, the N-terminus in green, the C-terminus in marine, and the J-helix in magenta. (B). View of the CYP1A2 catalytic site, the bound α-naphthoflavone is coloured yellow and the heme is in red.