Table 6: Percentages of Compounds Falling into Good Prediction, Under Prediction and Over Prediction and r Values Using Model A, B, and C (N=29)

Model	% of Compounds			r
	Good Prediction	Under Prediction	Over Prediction
Well-stirred model No binding (Model A) Including fu, plasma (Model B) Including fu, plasma and fu, S9 (Model C)	27.6 20.7 27.6	44.8 79.3 62.1	24.1 - 6.9	-0.07 0.24 0.06