Recombinant Human CYP Enzyme | Incubation Time (min) | [14C]-VNP40101M (µM) | C-7 Formed Per Incubation (pmol) | [14C]-VNP40101M Detected Per Incubation (pmol) | Percent Loss of Substrate (%)1 |
---|---|---|---|---|---|
Insect cell control | 10 | 25 | NC | 5440 | 17.0% |
rCYP2A6 + b5 2 | NC | 6490 2 | 8.0% 2 | ||
rCYP2C8 + b5 | NC | 5440 | 16.9% | ||
rCYP2C9 + b5 | NC | 5470 | 16.5% | ||
rCYP2C19 + b5 | NC | 5390 | 17.6% | ||
rCYP3A4 + b5 | 362 | 5150 | 21.3% | ||
Insect cell control | 100 | NC | 20100 | 14.6% | |
rCYP2C8 + b5 | NC | 19600 | 16.8% | ||
rCYP2A6 + b5 2 | NC | 21600 2 | 7.4% 2 | ||
rCYP2C9 + b5 | NC | 19900 | 15.6% | ||
rCYP2C19 + b5 | NC | 19400 | 17.5% | ||
rCYP3A4 + b5 | 549 | 18700 | 20.4% |