Table 1: RBC Concentrations of ATP and other Adenine Nucleotides
| Biomarkers/Treatment |
Average over 6 hours |
Before the experiment (Time 0) |
At the end of 6 hours (Time 6) |
| ATP control (mM) |
0.95 ± 0.48a
|
0.85 ± 0.76 |
1.04 ± 0.77 |
| ATP DTZ (mM) |
0.92 ± 0.69 |
0.85 ± 0.76 |
1.04 ± 0.77 |
| ATP amlodipine (mM) |
0.94 ± 0.25 |
0.74 ± 0.21 |
1.08 ± 0.22*
|
| ATP losartan (mM) |
0.90 ± 0.28 |
0.76 ± 0.29 |
1.04 ± 0.28*
|
| ATP dipyridamole (mM) |
0.94 ± 0.50 |
0.80 ± 0.38 |
1.16 ± 0.39 |
| ADP control (mM) |
0.53 ± 0.18 |
0.53 ± 0.22 |
0.55 ± 0.28 |
| ADP DTZ (mM) |
0.60 ± 0.34 |
0.62 ± 0.30 |
0.62 ± 0.49 |
| ADP amlodipine (mM) |
0.82 ± 0.081**
|
0.69 ± 0.097 |
0.84 ± 0.18 |
| ADP losartan (mM) |
0.75 ± 0.12 |
0.77 ± 0.19 |
0.75 ± 0.14 |
| ADP dipyridamole (mM) |
0.40 ± 0.085 |
0.52 ± 0.21 |
0.42 ± 0.087 |
| AMP control (mM) |
0.31 ± 0.39 |
0.25 ± 0.26 |
0.33 ± 0.43 |
| AMP DTZ (mM) |
0.42 ± 0.47 |
0.53 ± 0.64 |
0.38 ± 0.45 |
| AMP amlodipine (mM) |
0.27 ± 0.067 |
0.22 ± 0.073 |
0.30 ± 0.13 |
| AMP losartan (mM) |
0.22 ± 0.058 |
0.24 ± 0.074 |
0.22 ± 0.059 |
| AMP dipyridamole (mM) |
0.048 ± 0.020 |
0.11 ± 0.083 |
0.048 ± 0.036 |
| GTP control (mM) |
0.098 ± 0.043 |
0.081 ± 0.043 |
0.11 ± 0.059*
|
| GTP DTZ (mM) |
0.11 ± 0.073 |
0.088 ± 0.063 |
0.13 ± 0.10*
|
| GTP amlodipine (mM) |
0.13 ± 0.022 |
0.11 ± 0.034 |
0.18 ± 0.069 |
| GTP losartan (mM) |
0.088 ± 0.044 |
0.075 ± 0.024 |
0.094 ± 0.045 |
| GTP dipyridamole (mM) |
0.075 ± 0.027 |
0.048 ± 0.023 |
0.11 ± 0.045*
|
a Data are mean ± SD.
* p < 0.05 vs Time 0.
** p < 0.05 vs Control.