|
|
Low risk subjects (<10%) |
High risk subjects (≥10% |
p value |
|
|
No. of patients % |
12 |
4 |
n.s. |
|
|
Males/females ratio |
9/3 |
3/1 |
n.s. |
|
|
Mean age ± SD (years) |
41 ± 16 |
46 ± 22 |
n.s. |
|
| No. of patients (%) |
|
|
|
| - with current cigarette smoking |
5 (41.6) |
2 (50) |
n.s. |
| - arterial hypertension |
2 (16.6) |
0 |
n.s. |
| - family history of coronary heart disease |
0 |
1 (25) |
n.s. |
|
|
Mean duration of HIV infection ± SD (years) |
9.1 ± 4.2 |
9.8 ± 4.7 |
n.s. |
|
|
No. of patients (%) with AIDS diagnosis |
2 (16.6) |
1 (25) |
n.s. |
|
|
Mean CD4 lymphocyte count ± SD (cells/mm3) |
611 ± 279 |
649 ± 302 |
n.s. |
|
|
No. of patients (%) with undetectable HIV viral load (HIV RNA < 50
copies/mL) |
9 (75) |
3 (75) |
n.s. |
|
|
Mean duration of HAART ± SD (months) |
73 ± 35 |
78 ± 39 |
n.s. |
|
|
No. of patients (%) currently treated with |
|
|
|
| - NNRTIs |
5 (41.7) |
2 (50) |
n.s. |
| - PIs |
7 (58.3) |
2 (50) |
n.s. |
|
|
Mean concentration of total cholesterol ± SD (mg/dL) |
205 ± 102 |
259 ± 135 |
0.006 |
|
|
Mean concentration of LDL cholesterol ± SD (mg/dL) |
123 ± 65 |
180 ± 92 |
0.002 |
|
|
Mean concentration of HDL cholesterol ± SD (mg/dL) |
54 ± 20 |
47 ± 19 |
n.s. |
|
|
Mean concentration of triglycerides ± SD (mg/dL) |
132 ± 69 |
268 ± 144 |
0.003 |
|
|
Mean concentration of glucose ± SD (mg/dL) |
75 ± 33 |
71 ± 27 |
n.s. |
|
|
Mean waist circumference ± SD (cm) |
90 ± 46 |
94 ± 49 |
n.s. |
|
|
Mean BMI ± SD (Kg/m2) |
23.6 ± 11.1 |
24.8 ± 11.4 |
n.s. |
|
|
No. of patients (%) with metabolic syndrome |
0 |
2 (50) |
n.s. |
|
|
No. of patients (%) |
|
|
|
| - with lipodystrophy syndrome |
4 (33.3) |
4 (100) |
|
| - lipoatrophy |
1 (8.3) |
2 (50) |
0.001 |
| - lipohypertrophy |
2 (16.6) |
2 (50) |
|
| - mixed form |
1 (8.3) |
0 |
|
|
|
Mean 10-year risk of MI ± SD (%) |
3.4 ± 1.3 |
18.9 ± 9.5 |
<0.001 |
|
|
Mean IMT ± SD (mm) |
|
|
|
| - right common carotid artery |
0.75 ± 0.32 |
1.44 ± 0.81 |
0.007 |
| - left common carotid artery |
0.72 ± 0.33 |
1.51 ± 0.86 |
0.005 |
| - right carotid bifurcation |
0.92 ± 0.56 |
1.48 ± 0.77 |
0.004 |
| - left carotid bifurcation |
0.89 ± 0.52 |
1.46 ± 0.69 |
0.004 |
| - right internal carotid artery |
0.95 ± 0.56 |
1.52 ± 0.64 |
0.002 |
| - left internal carotid artery |
0.99 ± 0.59 |
1.49 ± 0.61 |
0.004 |
|
|
No. of patients (%) with carotid plaques |
4 (33.3) |
3 (75) |
0.047 |
|
| No. of carotid plaques (%) |
0 |
0 |
n.s. |
| - iso-hypoechogenic |
4 (100) |
3 (100) |
n.s. |
| - iso-hyperechogenic |
|
|
|
|
| No. of carotid plaques (%) with parietal and endoluminal portions
appearing |
0 |
0 |
n.s. |
| - homogeneous |
4 (100) |
3 (100) |
n.s. |
| - irregular |
|
|
|
n.s., no significant; SD, standard deviation; AIDS, acquired immunodeficiency syndrome; HAART, highly active antiretroviral therapy; NNRTIs, non-nucleoside reverse transcriptase
inhibitors; PIs, protease inhibitors; LDL, low-density lipoprotein; HDL, high-density lipoprotein; BMI, body mass index; MI, myocardial infarction; IMT, intima-media thickness