Table 5: Plasma syndecan-1, plasma hormone levels and urine analyses in hypertensive patients and healthy controls.
|
Controls |
Patients |
|
Plasma |
Total (n=56) |
Dipper (n=46) |
Non-dipper (n=10) |
Total (n=75) |
Dipper (n=51) |
Non-dipper (n=24) |
p-total |
Syndecan-1, ng/mL |
9.3 [7.9;17.9] |
8.8 [7.9;16.5] |
10.6 [7.9;23.4] |
14.0 [8.2;20.8] |
14.2 [8.5;19.2] |
11.3 [7.9;26.9] |
0.039 |
Aldo, pmol/L |
88.1 (49.1) |
88.5 (47.7) |
86.3 (57.5) |
98.3 (57.0) |
97.3 (52.7) |
100.6 (66.5) |
0.28 |
AngII, ng/L |
8.0 [5.3;10.8] |
8.0 [6.0;10.3] |
7.0 [4.8;12.3] |
9.0 [5.0;18.0] |
10.0 [5.0;22,0] |
9.0 [5.0;17.0] |
0.17 |
PRC, ng/L |
6.1 [4.4;8.8] |
6.4 [4.7;8.9] |
4.5 [4.1;7.8] |
12.7 [5.6;31.9] |
15.2 [6.0;43.0] |
11.8 [4.9;19.1] |
<0.0001 |
AVP, ng/L |
0.4 [0.3;0.5] |
0.4 [0.3;0.5] |
0.4 [0.3;0.5] |
0.4 [0.3;0.5] |
0.4 [0.2;0.5] |
0.4 [0.3;0.4] |
0.55 |
BNP, pmol/L |
4.4 [2.9;7.7] |
4.4 [2.9;7.7] |
4.4 [2.9;8.7] |
4.0 [2.9;6.8] |
3.66 [2.88;7.38] |
4.68 [3.62;7.38] |
0.73 |
Urine |
|
|
|
|
|
|
|
24h u-Na, mmol/24h |
144 (47) |
143 (47) |
152 (49) |
155 (53) |
159 (57) |
147 (43) |
0.23 |
AQP2, ng/min |
0.94 [0.78;1.34] |
0.92 [0.78;1.34] |
1.11 [0.70;1.55] |
1.10 [0.87;1.40] |
1.23 [0.86;1.44] |
1.05 [0.93;1.29] |
0.14 |
ENaCɣ, ng/min |
0.82 [0.67;1.21] |
0.80 [0.65;1.11] |
1.02 [0.67;1.37] |
1.02 [0.81;1.30] |
1.05 [0.81;1.31] |
1.01 [0.78;1.20] |
0.016 |
Abbreviations: Aldo: Aldosterone, AQP2: urine excretion of aquaporin-2, AngII: angiotensin II, AVP: arginine vasopressin, BNP: brain natriuretic peptide, ENaCɣ: urine excretion of epithelial sodium channel ɣ, 24h u-Na: 24-h urinary sodium excretion, PRC: plasma renin concentration.
Aldo and 24h u-Na are presented as mean (SD). The remaining are presented as median with interquartile range [25;75%].
Unpaired t-test or Mann Whitney’s test was made between cases and controls; the p-value of this test is shown in the table.
Unpaired t-test or Mann Whitney’s test was also performed between dippers and non-dippers within the case and within the control group; this showed no significance.