| # | Author | Total, n | Age, yrs | LGE Quantification | LGE+ | Mean LVEF, % | Wall thickness | NYHA Class I/II/≥III | Key Outcomes |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Dumont et al. [16] |
104 | 51 | Visual assessment, presence of LGE per segments |
48% | Per LGE+ LV segments ▪ 1 Segment 76 (7) ▪ 2 Segments 74 (8) ▪ 3 Segments 70 (9) ▪ 4 segments 69 (10) p=0.001 |
Per LGE+ segments ▪ 1 Segment 171 (67) ▪ 2 Segments 200 (75) ▪ 3 Segments 237 (74) ▪ 4 Segments 252 (91) (p<0.001) |
I: 50% II: 48% ≥III: 2% |
LGE+/NSVT+ ▪ 1 Segment (14%) ▪ 2 Segments (17%) ▪ 3 Segments (20%) ▪ 4 Segments (37%) (p=0.04) |
| 2 | Paya et al. [18] |
120 | 47±16 | Semi-automatic quantification | 69.2% | LGE+ 68±12 LGE- 64±9 (p=0.021) |
MWT, mm LGE+ 22±5 LGE- 17±3 (p<0.001) |
I: 41% ≥II: 59% |
NSVT+/LGE+ 38% vs NSVT+/LGE- 8% (p=0.001). LGE+ yielded an OR 8.19 (95%CI 1.38-48.53; p=0.020) for NSVT. |
| 3 | Dimitrow et al. [20] |
47 | 42 ± 12 | Visual quantification | N/A | NSVT+ 68±9 NSVT- 70±5 p>0.05 |
LV Mass, g NSVT+ 233 ± 80 NSVT-215 ± 64 p>0.05 |
N/A | NSVT+/LGE+ 97% NSVT-/LGE+ 60% (p<0.05) |
| 4 | Leonardi et al. [21] |
108 | 42±15 | Visual assessment (segmental LGE presence) | 85% | VT/VF- 62.1+8.8 VT/VF+ 60.2+12.3 (p=0.34) |
LV Mass index, g/m2 VT/VF - 79 (67–100) VT/VF+ 85 (76–115) (p=0.016) |
I: 78% II: 18.5% ≥III: 3.5% |
Total LGE score was the sole predictor for VT/VF on multivariate analysis (p=0.004) |
| 5 | Kwon et al. [7] |
60 | 51±14 | >2SD, semi automatic quantification | 63% | LGE+ 64±3 LGE- 65±4 (p=0.2) |
MWT, cm LGE+ 2.3±0.7 LGE- 1.8±0.2 (p=0.008) |
≥III: 100% | VT+/LGE+ 27% vs VT+/LGE- 5% (p=0.03) |
| 6 | Adabag et al. [22] |
177 | 41±16 | ≥6SD, semi-automatic quantification | 41% | N/A | MWT, mm LGE+ 23.5±5 LGE- 19.5±4 (p=0.0001) |
I: 77% II: 18% ≥III: 5% |
LGE+/NSVT+ vs LGE-/NSVT+ 28% vs 4% (p<0.0001). In LGE+ patients RR for NSVT 7.3, (95% CI 2.6-20.4; p<0.0001). |
| 7 | Kwon et al. [23] |
68 | 44 (34-56) | >2SD, semi automatic quantification | 57% | N/A | AUC 0.80 (p<0.001) for septal thickness to predict LGE |
N/A | NSVT+/LGE>18% 50% NSVT+/LGE<18% 11% (p<0.002) |
| 8 | Appelbaum et al. [24] |
145 | 43±15 | High intensity LGE ≥6SD Intermediate intensity LGE 6-4SD |
50% of initial cohort of 288 | No statistically significant difference between groups | No statistically significant difference between groups | I: 64% ≥II: 36% |
Mean LGE (≥6SD) % in NSVT+ 15.1±5.5% Mean LGE (≥6SD) % in NSVT- 9.1±6.3% (p<0.005) |