| Study No | Author | Total, n |
Age, yrs |
Follow up | Mean LVEF total, %l |
Mean LVMI total, g/m2 |
LGE Quantification |
LGE+, % | Mean LVEF, % | Mean LVMI, g/m2 |
Primary Endpoint | Outcomes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LGE + |
LGE - |
LGE + |
LGE - |
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| 1 | Prinz et al. [25] | 87 | 49.9± 13.6 | 3.5±2.6 years | 61.8± 7.5 | Maximal IVS thickness 22.0±8.0 mm | Visual quantification | 90% | N/A | N/A | ▪ Appropriate ICD interventions | LGE extent correlated with VT (p<0.01) in multilinear regression | ||
| 2 | Bruder et al. [26] |
220 | 58 (47-68) | 1090 days | 71 (65-77) | 84 (68-97) | >2SD | 67.2 | 71.0 vs 70.5 (p= 0.95) |
85.0 vs 76.0 (p=0.001) | ▪ SCD | LGE presence yielded an OR 5.14 for SCD, (p=0.057) | ||
| 3 | O’Hanlon et al. [27] |
217 | 53.2±15.1 | 3.1±1.7 years | 73.9 (10.6) | 108.9 (37.4) | FWHM | 63 | 72.7 (11.6) vs 75.9 (8.4) (p=0.03) |
118.2 (41.3) vs 93.2 (22.3) (p<0.001) | Composite arrhythmic endpoint ▪ Sustained VT or VF ▪ Appropriate ICD discharge ▪ SCD |
LGE presence yielded a HR 3.15 for the arrhythmic endpoint, (p=0.138). |
||
| 4 | Rubinshtein et al. [28] |
424 | 55±16 | 43±14 months | 67±9 (30 - 88) |
Maximal IVS thickness 20.5±5 mm | Visual quantification | 57 | 66±10 vs 69±8 (p=0.001) | N/A |
▪ SCD ▪ Appropriate ICD discharge ▪ SCD |
4 SCD + 4 appropriate ICD discharge all LGE+. | ||
| 5 | Klopotowski et al. [29] | 328 | 45 (29-58) | 37 (24-48) | 69 (63-75) |
87 (67-114) | >6SD | 68.9 | 70 (64-75) vs 68 (63-75) vs 69 (63-73) (p=0.384) |
93 (71-128) vs 90 (71-114) vs 77 (61-105) (p=0.003) |
▪ SCD ▪ Appropriate ICD discharge ▪ SCD |
LGE presence outside interventricular insertion points yielded an OR 10.01 for the endpoint, (p=0.033) | ||
| 6 | Ishmail et al. [30] |
711 | 56.3 | 3.5 years | 74.6±9 | 101.9±37.0 | FWHM | 66.2 | 73.3±9.5 vs 77.1±7.1 (p<0.001) | 108.4±40.1 vs 88.7±25.1 (p<0.001) |
▪ SCD ▪ Aborted SCD |
LGE presence yielded a HR: 2.69, p=0.073) LGE extent yielded a HR 1.24/5% increase in LGE (p=0.007) LGE not predictive of SCD in multivariate analysis |
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| 7 | Chan et al. [31] | 1293 | 46±17 years | 3.3 | 67±9 | 83.0±34.0 | Visual quantification | 42 | N/A | N/A |
▪ SCD ▪ Appropriate ICD discharge |
LGE extent yielded an adjusted HR, 1.46/10% increase in LGE (p=0.002) | ||