The Identification of Insulin Saturation Effects During the Dynamic Insulin Sensitivity Test

Table 2: SI Metrics from the Proportional Model, the Proposed Saturative Model and the SG Free Variable Model

Model Parameters		Intra – Subject Variability	Normalised Error I, G	Total Mean (CV)	NGT Mean (CV)	IFG-T2DM Mean (CV)	p-Value
Proportional Model	SI_L^*	13.8%	1.004 1.076	14.38^* (61.5%)	16.66^* (50.4%)	6.18^* (76.2%)	<0.001
Saturation Model	SI_S^*	40.1%	0.991 0.928	36.58^* (151.6%)	38.57^* (150.9%)	29.42^* (157.3%)	0.65
Saturation Model	I₅₀^†	55.6%	0.991 0.928	139.33^† (130.5%)	106.67^† (98.9%)	226.4^† (131.3%)	0.092
SG free var. Model	SI_G^*	15.8%	1.004 0.996	14.54^* (62.1%)	16.91^* (50.0%)	5.99^* (82.8%)	<0.001
SG free var. Model	SG^‡	88.2%	1.004 0.996	68.10^‡ (168.3%)	67.81^‡ (184.6%)	69.12^‡ (99.3%)	0.97

All metrics are shown as the mean of the full study population metrics and coefficient of variations (CV) of those metrics. Equation 10 defines the intra-subject variation. The mean residual errors produced are derived by finding the mean error between the measured data and the re-simulated profiles for insulin and glucose. The p-values are derived with Student’s t-test between the NGT and IFG-T2DM subgroups

^* e^-4L·mU^-1·min^-1

^† mU·L^-1

^‡ e^-4min^-1).