Table 2: Functional enrichment analysis of 300 human genes known to be mutated in neuropsychiatric disorders.

Category Feature n (%) p value FDR
Biological Process (GO) Nervous system development 76/294 (25.9) 1,6E-23 a 2,8E-20
Biological Process (GO) Transmission of nerve impulse 39/294 (13.3) 2,3E-18 a 4,1E-15
Cellular Component (GO) Neuron projection 43/294 (14.6) 3,8E-24 a 5,2E-21
Molecular Function (GO) Ion channel activity 29/294 (9.9) 2,1E-10 a 3,1E-7
Signaling Pathways (KEGG) Wnt signaling pathway 8/300 (2.7) 0.0008 b 0.03
Signaling Pathways (KEGG) Notch signaling pathway 5/300 (1.7) 0.0003 b 0.01
Signaling Pathways (KEGG) Long-term potentiation 5/300 (1.7) 0.001 b 0.04
Signaling Pathways (KEGG) MAPK signaling pathway 11/300 (3.7) 0.001 b 0.03
Protein-Protein Interaction Networks Relative betweenness 0.01 c
Protein-Protein Interaction Networks Connections 0.01 c
Protein-Protein Interaction Networks Clustering Coefficient 0.0007 c

a. DAVID server
b. FatiGO server
c. SNOW server
Abbreviations: GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes; MAPK: Mitogen-activated protein kinases; FDR: False Discovery Rate.