| First Author and Year | Type of Study | Number of Participants | Participant Sex | Mean age (range) in years | Diagnoses of Participants | Mean Duration of Symptoms (range) in Years |
|---|---|---|---|---|---|---|
| Tsui (1993) [10] | Cross-over trial | 20 | 7F 13M |
41 (28–58) | 20 WC | 5.2 (2–14) |
| Cole (1995) [11] | Cross-over trial | 10 | 7F 3M |
49 (36–66) | 6 WC 2 SC 2 MC |
8.5 |
| Kruisdijk (2007) [12] | Parallel-group trial | BTX-A group: 20 |
10F 10M |
BTX-A Group: 48 |
39 WC | BTX-A Group: 7.4 |
| Placebo: 19 | 7F 12M |
Placebo: 46 | Placebo: 9.1 |