Fig. (3) A. Evidence of B and T lymphocyte depletion in reduced germinative centers. Immunostaining demonstrated sinusoid expansion due to histiocytes, edema and hemorrhage. No evidence of viral cytopathic effect granuloma or necrosis. The pattern was reactional. B. T lymphocytes and blasts show atypical nuclei, histiocytes with hemosiderin and red blood cells in the stroma. Immunohistochemical study with positive detection of CD3, CD5, CD20, CD23 and BCL-2 and negative for CD10 and cyclin D1. Negative results for acid-fast bacilli and fungal infection tests using PAS coloration, Ziel-Neelsen and Grocott methods.