Table 1: ACE Polymorhisms in Patients with Idiopathic Parkinson’s Disease (PD) and Non-PD Controls

PD patients non-PD controls Total
No. of subjects 77 50 127
No. of chromosome 154 100 254
Allele frequency
No. % No. % No. %
D 97 63.0 57 57.0 154 60.6
I 57 37.0 43 43.0 100 39.4
P=0.6*
No. % UPDRSm UPDRS total H&Y ADL Age at onset No. % No. %
Mean (SD) Mean (SD) Mean (SD) Mean (SD) Mean (SD)
Genotype frequency
DD 30 39.0 34.4(21.3) 57.5(37.6) 2.8(1.1) 69.3%(22.7%) 61.8(12.7) 16 32.0 46 36.2
DI 37 48.1 26.8(19.8) 44.7(31.8) 2.3(1.0) 77.3%(19.7%) 63.5(10.7) 25 50.0 62 48.8
II 10 13.0 37.1(21.5) 60.3(39.4) 3.0(1.7) 55.0%(37.2%) 63.4(9.7) 9 18.0 19 15.0
P=0.16** P=0.23** P=0.09** P=0.16** P=0.98** P=0.6*
DD 30 39.0 34.4(21.3) 57.5(37.6) 2.8(1.1) 69.3%(22.7%) 61.8(12.7) 16 32.0 46 36.2
DI&II 47 61.0 29.0(20.4) 48.0(33.7) 2.4(1.2) 72.5%(25.7%) 63.5(10.4) 34 68.0 81 63.8
P=0.16*** P=0.46*** P=0.09*** P=0.31*** P=0.92*** P=0.5*

UPDRSm: motor part of the UPDRS scale; H&Y: Hoehn and Yahr scale; ADL: Activities of daily living scale; SD: standard deviation.
* p value for the comparison of allele frequencies between PD patients and controls.
** p value for the comparison UPDRSm, UPDRS total, H&Y, ADL and age at onset between PD patients of different genotype groups (DD, DI, II).
*** p value for the comparison UPDRSm, UPDRS total, H&Y, ADL and age at onset between PD patients of different genotype groups (DD vs DI and II).
D/I: deletion/insertion polymorphism; PD: Parkinson’s disease.