Table 2: MRI Findings According to RLS Case Status

RLS cases N = 26 controls N = 241 p6 p7
Dichotomous outcomes Odds Ratio [95% CI]
All stroke 1 30.8% (8) 18.3% (44) 0.13 2.46 [0.97 – 6.28]4 0.06
Silent infarction 2 19.2% (5) 12.0% (29) 0.30 2.11 [0.71 – 6.27] 4 0.18
LargeSCL (>= 10mm) 3 42.3% (11) 36.9% (89) 0.60 1.35 [0.56 – 3.22] 4 0.50
Continous outcomes RLS cases N = 26 controls N = 241 p6 Regression coefficient β [95% CI] p7
Subcortical lesion volume, log-transformed mean, ml -0.92 -1.06 0.75 0.20 [-0.69 – 1.08] 5 0.66
Cerebral atrophy score, mean 8.96 8.58 0.48 0.56 [-0.44 – 1.56] 5 0.27

For Dichotomous outcomes numbers in parentheses equal number of patients.
1 Detected by MRI and/or by clinical history validated through medical record review.
2 Defined as an answer “no” to the question about physician diagnosed stroke but with an ischemic lesion on MRI.
3 SCL denotes large subcortical lesion.
4 Odds ratio and its 95% confidence interval, derived from logistic regression analysis with RLS status, age, gender and co morbidities as independent variables.
5 Regression coefficient and its 95% confidence interval, derived from linear regression analysis with RLS status, age, gender and co morbidities as independent variables.
6 Unvariate p-value.
7 P-value corresponding to the confidence interval.