Prevalence of stroke in Restless Legs Syndrome: Initial Results Point to the Need for More Sophisticated Studies

Table 3: Sensitivity, Specificity, Positive and Negative Predictive Values and their 95% Confidence Intervals for RLS as a Marker for Stroke

	RLS Cases	Controls
	Total#RLS	Stroke	#No Stroke	Total#CTL	Stroke	#No Stroke	Sensitivity (CI)	Specificity(CI)	Pos Pred Value (CI)	Neg Pred Value (CI)
All Stroke	26	8	18	241	44	197	0.15 (0.06,0.25)	0.92 (0.88,0.95)	0.31 (0.13,0.49)	0.82 (0.77,0.87)
Silent Stroke	26	5	21	241	29	212	0.15 (0.03,0.27)	0.91 (0.87, 0.95)	0.19 (0.04,0.34)	0.88 (0.84,0.92)
Large SCL	26	11	15	241	89	152	0.11 (0.05,0.17)	0.91 (0.87, 0.95)	0.42 (0.23,0.61)	0.63 (0.57,0.69)

sensitivity = number of pts with RLS and stroke / total number of pts with stroke.specificity = number of pts without RLS and without stroke / total number of pts without stroke.pos predictive value = # of pts with RLS and stroke / # of pts with RLS.negative predictive value = # of pts without stroke and without RLS / # of pts without RLS.CI = 95% confidence interval for the proportion.SCL = Subcortical Lesion.