Table 1: Patient Information on the Two Individuals with Parkinson’s Disease (PD) Heterozygous for the DJ-1 Mutation Ala167Ala (c.501A>G, rs71653621) in Exon 7

Sex Family history Age at sampling Age of onset Brief history
CASE 1 Female Brother With PD 71 69 Moderately advanced PD, ON/OFF with some motor fluctuations but dominating non-motor symptoms in off.
CASE 2 Male No known heredity 65 48 Benign course. Minimal motor fluctuations but walking unassisted after 24 years disease. Diagnosed with Alzheimer’s disease as well at age 66.