Table 3: Stratification of Parkinson’s Disease (PD) Cases into Early (≤50 years) and Late Onset (>50 years), Comparing MIRO1 and MIRO2 Genotype Frequencies Analyzed using a Two-sided Chi-square (χ2) Test
|
Genotype Frequency % (n) |
χ2
|
P-value |
| MIRO1 |
| rs16967164 |
AA |
AG |
GG |
|
|
| ≤50 PD |
62.3 (33) |
40.0 (18) |
3.8 (2) |
0.45 |
0.80 |
| >50 PD |
66.7 (118) |
31.1 (55) |
2.2 (4) |
0.06 |
0.97 |
| Controls |
66.3 (203) |
31.1 (95) |
2.6 (8) |
|
|
| MIRO2 |
| rs1139897 |
GG |
GA |
AA |
|
|
| ≤50 PD |
49.1 (26) |
45.3 (24) |
5.7 (3) |
0.79 |
0.67 |
| >50 PD |
59.6 (106) |
32.0 (57) |
8.4 (15) |
3.51 |
0.17 |
| Controls |
51.1 (155) |
40.3 (122) |
8.6 (26) |
|
|
| rs3743912 |
CC |
CT |
TT |
|
|
| ≤50 PD |
77.4 (41) |
22.6 (12) |
0 |
- |
- |
| >50 PD |
72.2 (127) |
25.6 (45) |
2.3 (4) |
1.63 |
0.44 |
| Controls |
76.9 (233) |
21.8 (66) |
1.3 (4) |
|
|