Table 1: Conversion of Oral Levodopa to LCIG Equivalent

Oral Levodopa Dose LCIG (Duodopa 20 mg/ ml)
Calculated Morning Dose 80% of Oral Dose Calculated Continuous Dose 100% of Oral Dose
Morning dose 100 mg 100 mg / 20 mg/ml = 5 ml
Total daily dose 1000 mg 1000 mg 100 mg = 900 mg
900 mg / 20 mg/ml = 45 ml
45 ml Duodopa / 16 hours = 2.8 ml/hour
LCIG Start- up dose 5.0 ml x 80% = 4.0 ml 2.8 ml / hour = 2.8 ml / hour

Example of how to calculate the LCIG morning and continuous dose from the oral Levodopa morning dose and total daily dose, respectively. In the example the patient receives 100 mg Levodopa as a morning dose and 1000 mg as the total daily oral dose. LCIG (Duopdopa®) is 20 mg/ ml). The LCIG morning dose is set at 80% of the oral Levodopa dose, and the continuous dose is set at 100% the total daily dose minus the morning dose.