Fig. (3) Low magnification of the hippocampal formation shows the distribution of t (3A - left) and Aβ (3B - right) in the case with the most advanced protein accumulation. Note that while some degree of overlap between τ and Aβ are present, significant areas such as in the region of the entorhinal cortex and subiculum, show Aβ in the absence of t. Scale bars = 1 mm.