Time (h) | Percentage drug release | Concentration of PTH in lungs (µg/mL) | AUC of Pulmonary pharmacokinetic (µgh/mL) | Concentration of PTH in blood (µg/mL) | AUC of plasma pharmacokinetic (µgh/mL) | |||||
---|---|---|---|---|---|---|---|---|---|---|
PTH nano.a | Pure PTH a | PTH nano. a | Pure PTH a | PTH nano. a | Pure PTH a | PTH nano. a | Pure PTH a | PTH nano. a | Pure PTH a | |
1 | 19.77 ± 0.89 | 38.51 ± 0.59 | 2.31 ± 0.03 | 4.56 ± 0.31 | 15.79±0.20 | 10.48 ± 2.31 | 0.09 ± 0.005 | 0.42 ± 0.03 | 1.16 ± 0.02 | 0.728 ± 0.01 |
2 | 24.65 ± 0.47 | 67.62 ± 2.95 | 2.07 ± 0.01 | 2.05 ± 0.09 | 0.096 ± 0.0003 | 0.14 ± 0.01 | ||||
3 | 26.38 ± 1.32 | 91.41 ± 1.22 | 2.03 ± 0.01 | 0.72 ± 0.06 | 0.079 ± 0.005 | 0.08 ± 0.01 | ||||
6 | 28.67± 0.69 | 99.84 ± 0.08 | 0.65 ± 0.04 | 0.18 ± 0.03 | 0.074 ± 0.003 | 0.001 ± 0.001 | ||||
12 | 33.02 ± 1.04 | --- | 0.28 ± 0.03 | -- | 0.028 ± 0.005 | --- | ||||
24 | 40.36 ± 1.47 | --- | 0.22 ± 0.02 | --- | 0.025 ± 0.001 | --- | ||||
a Values are mean ± standard deviation |