Table 3: Summary of Manifest Refraction by Visit (FAS Population).

- EYECRYL-SERT (N=41)
Parameter Descriptive
Statistics
Screening PO 01
Month
PO 03
Month
PO 06
Month
Sphere N 30 40 39 40
Mean (SD) -1.35 (2.52) 0.01 (0.50) 0.10 (0.48) 0.10 (0.55)
Median -1.00 0.00 0.00 0.00
Min, Max -7.00, 6.00 -1.00, 1.00 -1.00, 1.00 -1.00, 1.50
p-value - 0.0123 0.0078 0.0090
Sphere Ref Range [n(%)] < -0.5 19 (46.34%) 3 (7.32%) 2 (4.88%) 2 (4.88%)
-0.5 - +0.5 7 (17.07%) 30 (73.17%) 30 (73.17%) 29 (70.73%)
> +0.5 4 (9.76%) 7 (17.07%) 7 (17.07%) 9 (21.95%)
Cylinder N 30 40 39 40
Mean (SD) -1.18 (1.22) -0.62 (0.52) -0.63 (0.55) -0.62 (0.51)
Median -1.00 -0.50 -0.75 -0.50
Min, Max -5.50, 0.50 -2.00, 0.00 -2.00, 0.50 -2.00, 0.00
p-value - 0.0138 0.0174 0.0181
Cylinder Ref Range [n(%)] < -0.5 19 (46.34%) 18 (43.90%) 20 (48.78%) 18 (43.90%)
-0.5 - +0.5 11 (26.83%) 22 (53.66%) 19 (46.34%) 22 (53.66%)
> +0.5 0 (0.00%) 0 (0.00%) 0 (0.00%) 0 (0.00%)
Abbreviations: N=number of subjects in the specified treatment; n=number of subjects in the specified category.
Note 1: The given interval is inclusive of both values.
Note 2: When screening, visit data was not available. We considered 'PO 01 Month' visit data as baseline.
Note 3: p-value for parameter sphere obtained by using paired t-test and for cylinder by using Wilcoxon signed rank test.