Table 1: Differential characteristics of various drusen in AMD.

Different types of drusen	Sizes	Edges	Shape	Location	Risks related to AMD	References
Soft	Large (>125 ìm)	Distinct or indistinct edge	Dome-shaped	Central retina	Increases the risk of severe AMD and RPE pigmentation	[84, 85]
Hard	Small (<63 ìm)	Distinct edge	Round	Throughout the retina	Increases risk of presentation of soft drusen	[86]
Cuticular drusen	Small (25-75 ìm)	Uniformly sized, “stars in the sky” pattern	Triangular, saw tooth	Around fovea	Increases the risk of CNV	[86-88]
Reticular pseudodrusen	Large (100-250 ìm)	Irregular borders	Networks of oval or round lesions	Located on apical surface of RPE	Increases the risk of advanced forms of AMD	[89-92]