Table 1: Clinical Data of the CIN Specimens

No Age Gender Clinical Findings Treatment Prior to Excision Risk Factors Proposed Pathogenic Sequence Tumor Location
1 79 f Chronic conjunctivitis Cromoglycic acid None Primary CIN? Limbus, 16x6x4mm
2 67 m Conjunctivitis None None Primary CIN? Nasal and temporal limbus
3 39 m Red eye Vit A ointment None Primary CIN? Temporal limbus
4 73 m Corneal neoplasia None None Possibly primary CIN developing from a pinguecula Corneal at the limbus, adjacent to pinguecula
5 61 m Corneal neoplasia None None Primary CIN? Medial limbus with corneal part (2-3mm) 10x5x2mm
6 64 m At least 4 years ocular surface problems with circular pannus Topical steroids, antiviral ointment HPV 16 Malignant transformation due to HPV 16 Limbus with corneal part at 7 and 12h
7 67 m "Pterygium" since at least 3 years with unusual extension None None Primary CIN mimicking pterygium or CIN developing from altered epithelium of a pterygium Medial limbus with corneal part (2mm)
8 56 f Atypical Pterygium with whitish plaque and vascularisation None HPV 16 Malignant transformation due to HPV 16 Limbus, 11x7x1mm
9 61 m Red eye None None Primary CIN? Medial limbus with corneal part (2mm)
10 53 m Superficial vascularisation onto the cornea None Explosion injury 30 years previously DNA-damage due to the trauma and malignant transformation during repair phase Limbus with corneal part (2mm)
11 29 m Whitish neoplasia 1991 tectonic keratoplasty due to malignancy, 1992 rekeratoplasty due to corneal melting Xeroderma pigmentosum, UV-B radiation DNA-damage and malignant transformation due to UV-B radiation and defective repair mechanisms Limbus with corneal part (4mm) 4x4x2
12 67 m Red eye Dexpanthenol eye drops None Primary CIN? Medial limbus