Table 3: Differentiation Grade of the CIN Specimens and the Proportion of p16 and MIB-1 Positive Cells (Grade 4 = CIN with Beginning Invasion)
| No. |
Grade |
p16-Positive Cells |
MIB-1-Positive Cells |
HPV |
β-Actin |
| 1 |
1 |
66% (402/614) |
3% (15/510) |
- |
+ |
| 2 |
1 |
51% (263/521) |
4% (22/522) |
- |
+ |
| 3 |
2 |
57% (312/550) |
13% (72/552) |
- |
+ |
| 4 |
2 |
46% (258/558) |
16% (89/569) |
- |
+ |
| 5 |
2 |
41% (320/782) |
10% (72/694) |
- |
+ |
| 6 |
3 |
53% (378/720) |
16% (120/754) |
+ (type 16) |
+ |
| 7 |
3 |
41% (251/615) |
8% (70/831) |
- |
+ |
| 8 |
3 |
84% (536/639) |
18% (118/649) |
+ (type 16) |
+ |
| 9 |
3 |
59% (395/669) |
30% (183/613) |
- |
+ |
| 10 |
3 |
83% (598/725) |
12% (60/502) |
- |
+ |
| 11 |
4 |
27% (149/547) |
3% (15/539) |
- |
n.a. |
| 12 |
4 |
37% (247/664) |
8% (42/546) |
- |
+ |
| Mean ± SD |
|
53.6 ± 17.3 |
12% ± 8% |
|
|