JIA Categories | Definition | ILAR Exclusion Criteria |
---|---|---|
1. Oligoarticular JIA, Persistent and Extended |
Arthritis affecting four or fewer joints during the first 6 months of disease Persistent oligoarthritis: Arthritis in four or fewer joints for the entire disease course Extended oligoarthritis: Arthritis in five or more joints after the initial 6 months of disease |
(1) Psoriasis in the patient or a history of psoriasis in a first-degree relative; OR (2) Arthritis in an HLA-B27 male beginning after his sixth birthday; OR (3) Two positive tests for RF obtained at least three months apart; OR (4) HLA-Associated disease* in a first-degree relative; OR (5) Systemic arthritis |
2. RF-negative polyarticular JIA | Arthritis affecting 5 or more joints during the first 6 months of disease, with an RF negative test | (1) Psoriasis in the patient or a history of psoriasis in a first-degree relative; OR (2) Arthritis in an HLA-B27 male beginning after his sixth birthday; OR (3) Two positive tests for RF obtained at least three months apart; OR (4) HLA-Associated disease* in a first-degree relative; OR (5) Systemic arthritis |
3. RF-positive polyarticular JIA | Arthritis affecting 5 or more joints during the first 6 months of disease, with 2 or more positive tests for RF at least 3 months apart during the first 6 months of disease | (1) Psoriasis in the patient or a history of psoriasis in a first-degree relative; OR (2) Arthritis in an HLA-B27 male beginning after his sixth birthday; OR (3) HLA-Associated disease* in a first-degree relative; OR (4) Systemic arthritis |
4. Systemic arthritis | Arthritis in one or more joints with or preceded by fever of at least 2 weeks duration that is documented to be daily for at least 3 days, AND Accompanied by one or more of the following: 1. Evanescent erythematous rash 2. Generalized lymph node enlargement 3. Hepatomegaly and/or splenomegaly 4. Serositis |
(1) Psoriasis in the patient or a history of psoriasis in a first-degree relative; OR (2) Arthritis in an HLA-B27 male beginning after his sixth birthday; OR (3) Two positive tests for RF obtained at least three months apart; OR (4) HLA-Associated disease* in a first-degree relative |
5. Psoriatic arthritis | Arthritis and psoriasis, or arthritis and at least 2 of the following: 1. Dactylitis 2. Nail pitting or onycholysis 3. Psoriasis in a first-degree relative |
(1) Arthritis in an HLA-B27 male beginning after his sixth birthday; OR (2) Two positive tests for RF obtained at least three months apart; OR (3) HLA-associated disease* in a first-degree relative; OR (4) Systemic arthritis. |
6. Enthesitis-related arthritis | Arthritis and enthesitis, or arthritis or enthesitis with at least 2 of the following: 1. Presence or a history of sacroiliac joint tenderness and/or inflammatory lumbosacral pain 2. The presence of HLA-B27 antigen 3. Onset of arthritis in a male over 6 years of age 4. Acute anterior uveitis 5. History of ankylosing spondylitis, enthesitis related arthritis, sacroiliitis with inflammatory bowel disease, Reiter’s syndrome, or acute anterior uveitis in a first-degree relative |
(1) Psoriasis in the patient or a history of psoriasis in a first-degree relative; OR (2) Arthritis in an HLA-B27 male beginning after his sixth birthday; OR (3) Two positive tests for RF obtained at least three months apart; OR (4) Arthritis that fits 2 or more categories |
7. Undifferentiated arthritis | Arthritis that fulfills criteria in no category or in 2 or more of the above categories |