Table 3: Snapshot Of Key Findings Of Selected Representative Prospective Studies Published In PUBMED Between 2014 And 2020 And Examining The Impact Of Anxiety In The Context Of Osteoarthritis.

Research Group Key Findings and Conclusions
Ali et al. [53] Preoperative anxiety predicted dissatisfaction after knee arthroplasty surgery using the Hospital Anxiety and Depression Scale [HADS]
Alattas et al. [59] Greater anxiety predicted a worse post-surgical outcome following knee replacement surgery, hence a validated screening tool for anxiety was recommended before surgery, and efforts to intervene should be forthcoming accordingly
Cho et al. [70] No impact was noted of the effects of anxiety before total shoulder arthroplasty surgery for osteoarthritis as far as clinical outcomes are concerned, surgery improved psychological status as determined by the Hospital Anxiety and Depression Scale [HADS]
De Caro et al. [60] Psychological factors and mental status in primary total hip + knee replacement cases can affect outcome + patient satisfaction. Strategies to identify and intervene accordingly are needed to improve outcomes of total joint replacement surgery
Dhurve et al. [54] Patients with altered psychological profiles were less satisfied and functionally improved post-total knee arthroplasty surgery than those with normal profiles as measured by the Depression, Anxiety, and Stress Scale [DASS], Oxford Knee Score and goniometer- hence identifying and treating psychological distress as well as physical treatments may improve post-surgical satisfaction, as well as knee scores and range of motion
Ferreira et al. [40] Women with knee osteoarthritis, mean age 67 years, have higher rates of anxiety as assessed using the State Trait Anxiety Inventory [STAI] when compared to control; in addition, they have a lower quality of life on the SF-36 survey instrument
French et al. [56] Positive mental health predicted short term outcomes in hip osteoarthritis patients receiving exercise and manual therapy
Hanlandsmyth et al. [42] Pre-surgical anxiety was related to pain intensity and distress in patients scheduled for total knee arthroplasty, thus the possibility of brief psychological interventions before surgery was discussed
Hanusch et al. [57] Anxiety assessed by Hospital Anxiety and Depression Scale [HADS] questionnaire affected surgical outcomes of knee osteoarthritis cases, average age 71 years, negatively after undergoing total knee replacement in terms of worse knee function scores at 1 year, and should be taken into account when considering total knee replacement interventions
Helminen et al. [46] Anxiety predicted pain and function at one year in knee osteoarthritis cases
Hassett et al. [47] Presurgical affective symptoms not only have an effect on change in postsurgical pain, whereby lower preoperative scores on depression and anxiety were associated with lower postsurgical pain in patients undergoing lower extremity total joint arthroplasty surgery
Hiyama et al. [27] Patients reported similar levels of anxiety regarding wounds, pain, gait, and falling at discharge after total knee arthroplasty. The severity of anxiety symptoms at discharge was negatively associated with the patient reported outcomes scores related to the Knee Society Score six-months postoperatively
Jones et al. [19] Knee surgery cases are not impacted by pre-surgical anxiety
Khatib et al [60]. Among patients eligible for knee arthroplasty surgery, the distressed group had significantly worse knee pain, knee function, and general quality-of-health scores. It was concluded that psychological health is an important often overlooked predictor of symptom severity and dysfunction in patients with knee arthritis and should be treated to help improve post-operative outcomes
Legha et al. [45] Anxiety/depression predicted pain and function outcomes in people with knee osteoarthritis offered an exercise intervention
Liddle et al. [26] Anxiety affected 8 year outcomes after unicompartmental knee replacement
Kohan et al. [55] Anxiety impacts pain + function incrementally in glenohumeral osteoarthritis (p < .001)
O'Leary et al. [43] Higher anxiety levels partially predicted worse outcomes in non surgical intervention applications for knee osteoarthritis, hence clinicians need to consider this issue when designing management strategies for this group
Sofat et al. [69] A cross-sectional study of adults with mild and advanced knee osteoarthritis and healthy controls showed a multivariate analysis that indicated that body mass and the Hospital Anxiety and Depression Survey [HADS] scores were the most significant predictors of pain scores (p < 0.05)
Rasouli et al. [36] Anxiety increases complications after total knee joint arthroplasty surgery
Rice et al. [62] At 6 months after knee arthroplasty, a combination of preoperative pain intensity, expected pain, trait anxiety, and temporal summation was able to correctly classify 66% of patients into moderate to severe and no to mild persistent pain groups. At 12 months, preoperative pain intensity, expected pain, and trait anxiety correctly classified 66% of patients, implying a role for future intervention studies that aim to reduce the development of pain after surgery
Roger et al. [65] Factors predicting discharge to rehabilitation after hip or knee arthroplasty surgery were older age, female gender, chronic obstructive pulmonary disease, anxiety-depressive disorder, and a history of stroke. Risk factors for 30-day readmission were male gender, obesity, and discharge to the rehabilitation unit
Shang et al. [58] Long-term osteoarthritis, cardiovascular disease, and cancer were independent risk factors for incident depression and anxiety in both genders with osteoarthritis having the highest relative risk
Waimann et al. [64] Anxiety leads to some degree to higher total knee replacement-related costs in patients with knee osteoarthritis. Preoperative interventions targeting these factors may reduce these costs and prove cost-effective