Outcome |
Study (Hip, Knee, Both) |
Osteolysis |
No Osteolysis |
Healthy Control |
n |
Mean (SD) |
n |
Mean (SD) |
p-Value |
n |
Mean (SD) |
p-Value |
Collagen peptides |
|
|
|
|
|
|
|
|
|
Urinary cross-linked N-telopeptide
of type I collagen |
Antonioiu 2000 (hip) |
11 |
NA |
8A
|
NA |
p = 0.002 |
7 |
NA |
p = 0.0297 |
|
Von Schewelov 2006 (hip) |
33 |
34 bone collagen equivalents (BCE)/nM
creatinine (12) |
127A
|
29 BCE/nM Cr (15) |
p = 0.06 |
|
|
|
Serum C-terminal telopeptide of type
I collagen |
Arabmotlagh 2006 (hip) |
53 |
Significant correlation found
between bone mineral density loss in ROI 7 at 1 year with week 3 CTX-1
values (p = 0.002) |
|
|
|
Chemokines, Cytokines & other |
|
|
|
|
|
|
|
|
|
Interleukin (IL)-1β |
Fiorto 2003 (hip) |
8 |
2.15pg/ml (1.37) |
10A
|
2.26pg/ml (0.89) |
p = 0.96 |
17 |
2.02pg/ml (1.25) |
p = 0.79 |
|
Hernigou 1999 (hip) |
6 |
“Undetectable” |
10B
|
NA |
NA |
5 |
“undetectable” |
NA |
Tumor Necorsis Factor-α |
Fiorto 2003 (hip) |
8 |
4.32pg/ml (5.2) |
10A
|
3.84pg/ml (1.13) |
p = 0.62 |
17 |
3.42pg/ml (2.12) |
p = 0.95 |
|
Hernigou 1999 (hip) |
6 |
“undetectable” |
10B
|
NA |
NA |
5 |
“undetectable” |
NA |
IL-6 |
Fiorto 2003 (hip) |
8 |
2.86pg/ml (1.95) |
10A
|
4.58pg/ml (4.02) |
p = 0.24 |
17 |
3.88pg/ml (2.72) |
p = 0.36 |
|
Hernigou 1999 (hip) |
6 |
41pg/ml (17) |
10B
|
22pg/ml (6.7) |
p = 0.002 |
5 |
NA |
NA |
IL-11 |
Fiorto 2003 (hip) |
8 |
0pg/ml (0) |
10A
|
1.22pg/ml (2.57) |
p = 0.27 |
17 |
18.69pg/ml (10.55) |
p = 0.001 |
transforming growth factor (TGF)-β |
Fiorto 2003 (hip) |
8 |
23175pg/ml (8774) |
10A
|
21120pg/ml (13657) |
p = 0.50 |
17 |
23615pg/ml (10681) |
p = 0.88 |
matrix metalloproteinase-1 (MMP-1) |
Fiorto 2003 (hip) |
8 |
3.69pg/ml (1.75) |
10A
|
4.10pg/ml (1.44) |
p = 0.50 |
17 |
3.31pg/ml (1.7) |
p = 0.52 |
prostaglandin E-2 (PGE-2) |
Fiorto 2003 (hip) |
8 |
1330pg/ml (1097) |
10A
|
2021pg/ml (1046) |
p = 0.14 |
17 |
2893pg/ml (782) |
p = 0.005 |
Bone Alkaline Phosphatase (ALP) |
Arapmotlagh 2006 (hip) |
53 |
No significant correlation found
between bone mineral density loss in ROI 7 at 1 year with bone ALP
values |
|
|
|
Osteocalcin |
Arapmotlagh 2006 (hip) |
53 |
No significant correlation found
between bone mineral density loss in ROI 7 at 1 year with osteocalcin
values |
|
|
|
C-reactive protein |
Hernigou 1999 (hip) |
6 |
10mg/L (2.4) |
10B
|
7.7mg/L (2.8) |
p = 0.135 |
5 |
NA |
NA |
A Arthroplasty without osteolysis.
B Arthroplasty without osteolysis, >10 years post-op.
ROI = region of interest.