Table 1: Summary of screening of eligible studies.

Outcome Study (Hip, Knee, Both) Osteolysis No Osteolysis Healthy Control
n Mean (SD) n Mean (SD) p-Value n Mean (SD) p-Value
Collagen peptides
Urinary cross-linked N-telopeptide of type I collagen Antonioiu 2000 (hip) 11 NA 8A NA p = 0.002 7 NA p = 0.0297
Von Schewelov 2006 (hip) 33 34 bone collagen equivalents (BCE)/nM creatinine (12) 127A 29 BCE/nM Cr (15) p = 0.06
Serum C-terminal telopeptide of type I collagen Arabmotlagh 2006 (hip) 53 Significant correlation found between bone mineral density loss in ROI 7 at 1 year with week 3 CTX-1 values (p = 0.002)
Chemokines, Cytokines & other
Interleukin (IL)-1β Fiorto 2003 (hip) 8 2.15pg/ml (1.37) 10A 2.26pg/ml (0.89) p = 0.96 17 2.02pg/ml (1.25) p = 0.79
Hernigou 1999 (hip) 6 “Undetectable” 10B NA NA 5 “undetectable” NA
Tumor Necorsis Factor-α Fiorto 2003 (hip) 8 4.32pg/ml (5.2) 10A 3.84pg/ml (1.13) p = 0.62 17 3.42pg/ml (2.12) p = 0.95
Hernigou 1999 (hip) 6 “undetectable” 10B NA NA 5 “undetectable” NA
IL-6 Fiorto 2003 (hip) 8 2.86pg/ml (1.95) 10A 4.58pg/ml (4.02) p = 0.24 17 3.88pg/ml (2.72) p = 0.36
Hernigou 1999 (hip) 6 41pg/ml (17) 10B 22pg/ml (6.7) p = 0.002 5 NA NA
IL-11 Fiorto 2003 (hip) 8 0pg/ml (0) 10A 1.22pg/ml (2.57) p = 0.27 17 18.69pg/ml (10.55) p = 0.001
transforming growth factor (TGF)-β Fiorto 2003 (hip) 8 23175pg/ml (8774) 10A 21120pg/ml (13657) p = 0.50 17 23615pg/ml (10681) p = 0.88
matrix metalloproteinase-1 (MMP-1) Fiorto 2003 (hip) 8 3.69pg/ml (1.75) 10A 4.10pg/ml (1.44) p = 0.50 17 3.31pg/ml (1.7) p = 0.52
prostaglandin E-2 (PGE-2) Fiorto 2003 (hip) 8 1330pg/ml (1097) 10A 2021pg/ml (1046) p = 0.14 17 2893pg/ml (782) p = 0.005
Bone Alkaline Phosphatase (ALP) Arapmotlagh 2006 (hip) 53 No significant correlation found between bone mineral density loss in ROI 7 at 1 year with bone ALP values
Osteocalcin Arapmotlagh 2006 (hip) 53 No significant correlation found between bone mineral density loss in ROI 7 at 1 year with osteocalcin values
C-reactive protein Hernigou 1999 (hip) 6 10mg/L (2.4) 10B 7.7mg/L (2.8) p = 0.135 5 NA NA

A Arthroplasty without osteolysis.
B Arthroplasty without osteolysis, >10 years post-op.
ROI = region of interest.