Table 3: Association Analysis of the Structural, Inflammatory, Matrix Degradative, Vitamin D Receptor and Osteoarthritis Associated Gene Variants with LDD

SNP*** Gene Risk Allele RAF** Cases RAF Control OR*(95% CI) p Value
rs1042631 AGC1 T 0.212 0.176 1.27 (0.86-1.86) 0.23
rs1516797 AGC1 T 0.641 0.622 1.09 (0.79-1.50) 0.60
rs10735810 VDR A 0.401 0.370 1.14 (0.83-1.56) 0.41
rs731236 VDR A 0.603 0.568 1.16 (0.85-1.58) 0.35
rs2075555 COL1A1 G 0.873 0.864 1.08 (0.69-1.70) 0.74
rs917055 COL2A1 A 0.168 0.168 1.00 (0.67-1.51) 0.99
rs2056156 COL3A1 C 0.441 0.420 1.09 (0.80-1.48) 0.58
rs696990 COL9A1 C 0.210 0.173 1.27 (0.86-1.87) 0.22
rs7533552 COL9A2 T 0.757 0.731 1.14 (0.80-1.63) 0.45
rs61734651 COL9A3 C 0.942 0.939 1.05 (0.56-1.97) 0.87
rs1463035 COL11A1 T 0.810 0.797 1.08 (0.74-1.59) 0.68
rs1676486 COL11A1 A 0.229 0.217 1.07 (0.74-1.55) 0.72
rs2072915 COL11A2 T 0.731 0.714 1.09 (0.77-1.54) 0.62
rs2071375 IL1A C 0.700 0.670 1.15 (0.82-1.60) 0.42
rs2287037 IL18R1 C 0.668 0.596 1.36 (0.99-1.87) 0.06
rs1420100 IL18RAP A 0.493 0.422 1.33 (0.98-1.81) 0.07
rs1420106 1L18RAP A 0.253 0.239 1.08 (0.76-1.54) 0.68
rs917997 IL18RAP T 0.262 0.235 1.16 (0.81-1.65) 0.43
rs72520913 MMP3 A 0.497 0.470 1.11 (0.82-1.51) 0.50
rs5277 COX2(PTGS2) C 0.836 0.832 1.02 (0.68-1.54) 0.91
rs4140564 PTGS2(COX2) A 0.949 0.931 1.35 (0.72-2.56) 0.34
rs12885713 CALM1 C 0.451 0.406 1.20 (0.88-1.64) 0.25
rs11718863 DVWA A 0.842 0.824 1.14 (0.76-1.71) 0.54
rs7639618 DVWA C 0.842 0.824 1.14 (0.76-1.71) 0.54
rs288326 FZRP A 0.123 0.109 1.15 (0.72-1.84) 0.57
rs7775 FZRP C 0.083 0.059 1.42 (0.79-2.56) 0.24
rs143383 GDF5 A 0.651 0.629 1.10 (0.79-1.52) 0.57

* Odds ratio (95 % Confidence interval)
** Risk allele frequency
*** Single-nucleotide polymorphism.
§rs2287037, allele counts in cases: 66 CC, 63 CT, 17 TT; allele counts in controls: 62 CC, 100 CT and 26 TT.rs1420100, allele counts in cases: 37 AA, 69 AC, 39 CC; allele counts in controls: 29 AA, 98 AC and 58 CC.