| Osteoporosis | Structural failure/ increased intraosseous pressure/vascular compromise |
|---|---|
| Steroid therapy | Fatty tissue accumulation/crushing of the intramedullary vessels/ microscopic fat emboli in the end-arteries/secondary osteoporosis |
| Hemoglobinopathies | Vascular occlusion/ischemia |
| Vasculitides | Vascular occlusion/ischemia |
| Diabetes | Unknown |
| Alcoholism | Microscopic fat emboli in the end-arteries |
| Cushing’s disorder | Microscopic fat emboli in the end-arteries |
| Malignancy | Unknown |
| Infection | Unknown |
| Post-radiation changes | Direct cytotoxic effect with damage to vascularity |
| Pancreatitis | Pancreatic lipase in systemic circulation/Fat necrosis of bone marrow/ vascular compression/ microscopic fat emboli |
| Cirrhosis | Unknown |
| Sarcoidosis | Unknown |
| Gaucher type 1 | Accumulation of glycosyl ceramide in Gaucher cells/ marrow infiltration/vascular compromise |