The Open Orthopaedics Journal




ISSN: 1874-3250 ― Volume 13, 2019

Persistent Wound Drainage After Tumor Resection and Endoprosthetic Reconstruction of the Proximal Femur



Werner H. Hettwer, Peter F. Horstmann, Tomas A. Grum-Schwensen, Michael M. Petersen*
Musculoskeletal Tumor Section, Department of Orthopedic Surgery, Rigshospitalet, University of Copenhagen, Denmark

Abstract

Purpose:

To examine the prevalence of prolonged wound drainage (PWD) after tumor resection and endoprosthetic reconstruction of the hip.

Methods:

Retrospective review of 86 consecutive patients with metastatic bone disease, malignant hematologic bone disease or bone sarcoma, treated with tumor resection and subsequent endoprosthetic reconstruction of the proximal femur, between 2010 and 2012, in a single center.

Results:

PWD for 7 days or more was observed in 41 cases (48%). The wounds only ceased oozing after a mean of 8.4 days, leading to prolonged administration of prophylactic antibiotics (mean 8.7 days) and length of hospital stay (mean 10.2 days). Total femur replacement, bone sarcoma and additional pelvic reconstruction were identified as significant independent risk factors for an even longer duration of PWD.

Conclusion:

Compared to conventional hip arthroplasty, PWD appears to be significantly more prevalent in patients undergoing tumor arthroplasty procedures of the hip. Given the potentially increased risk for periprosthetic joint infection (PJI), increased awareness, identification and implementation of adequate strategies for prevention and treatment of this avoidable complication are warranted.

Keywords: Bone metastases, bone tumor resection, endoprosthesis, hip replacement, wound ooze, wound drainage.


Article Information


Identifiers and Pagination:

Year: 2014
Volume: 8
First Page: 475
Last Page: 481
Publisher Id: TOORTHJ-8-475
DOI: 10.2174/1874325001408010475

Article History:

Received Date: 19/7/2014
Revision Received Date: 8/11/2014
Acceptance Date: 3/12/2014
Electronic publication date: 29 /12/2014
Collection year: 2014

Article Metrics:

CrossRef Citations:
0

Total Statistics:

Full-Text HTML Views: 1306
Abstract HTML Views: 821
PDF Downloads: 221
Total Views/Downloads: 2348

Unique Statistics:

Full-Text HTML Views: 732
Abstract HTML Views: 496
PDF Downloads: 142
Total Views/Downloads: 1370
Geographical View

© Hettwer et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.


* Address correspondence to this author at the Department of Orthopedic Surgery U-2161, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark; Tel: +45 35458900; Fax: +45 35452211; E-mail: m.m.petersen@dadlnet.dk




INTRODUCTION

Patients, who undergo endoprosthetic reconstruction subsequent to malignant bone tumor resection, are at high risk of prosthetic joint infection (PJI) (10-11%), as established in two large reviews [1Racano A, Pazionis T, Farrokhyar F, Dehesi B, Ghert M. High infection rate outcomes in long-bone tumor surgery with endoprosthetic reconstruction in adults a systematic review Clin Orthop Relat Res 2013; 471(6): 2017-7., 2Jeys LM, Grimer RJ, Carter SR, Tillman RM. Periprosthetic infection in patients for an orthopaedic oncological condition J Bone Joint Surg Am 2005; 87(4): 842-9.]. Deep infection is a devastating complication, which may require further revision surgery, prolonged hospitalization, antibiotic treatment and rehabilitation. Moreover it exposes the tumor patient in particular, to significant further risks and complications, such as amputation [1Racano A, Pazionis T, Farrokhyar F, Dehesi B, Ghert M. High infection rate outcomes in long-bone tumor surgery with endoprosthetic reconstruction in adults a systematic review Clin Orthop Relat Res 2013; 471(6): 2017-7.-3Jeys L, Grimer R. The long-term risks of infection and amputation with limb salvage surgery using endoprostheses Recent Results Cancer Res 2009; 179: 75-84.] and may interfere with adjuvant radio- or chemotherapy, possibly even compromising overall survival. The substantial cost associated with treatment of these complications has also been well documented [4Hernández-Vaquero D, Fernández-Fairen M, Torres A , et al. Treatment of perioprosthetic infections an economic analysis Scientific World Journal 2013; 2013: 821650.]. Prolonged wound drainage (PWD) is a well known predisposing risk factor for surgical site infection [5Patel VP, Walsh M, Sehgal B, Preston C, DeWal H, Di Cesare PE. Factors associated with prolonged wound drainage after primary hip and knee arthroplasty J Bone Joint Surg Am 2007; 89(1): 33-8.-9Surin VV, Sundholm K, Backman L. Infection after total hip replacement with a special reference to discharge from the wound J Bone Joint Surg Br 1983; 65(4): 412-18.] and may result in prolonged hospital stay and delay of adjuvant therapy. While reported to occur in about 4% of conventional hip arthroplasties [10Jaberi MF, Eslampour A, Haytmanek CT, Parvizi J, Ghanem E, Purtill J. Persistent surgical wound drainage after total hip and knee arthroplasty – Risk factors and final outcome J Bone Joint Surg Br 2009; 91(12): SUPP II- 298.], PWD appears to be considerably more frequent in our tumor patients and as a consequence, it is our practice, to neither discharge the patient, nor to discontinue prophylactic intravenous antibiotics, before the surgical wound is dry. This study was conducted to investigate and quantify the prevalence of PWD, the duration of administration of postoperative intravenous antibiotic prophylaxis and the length of the hospital stay after endoprosthetic reconstruction of the proximal femur performed in patients with a primary or secondary malignancy of bone.

MATERIALS AND METHODS

Study Design and Patient Population

We retrospectively reviewed the medical records of all patients with metastatic bone disease, malignant hematologic bone disease and bone sarcoma, who underwent endoprosthetic reconstruction of the proximal femur in our specialized orthopedic oncology unit between 2010 and 2012. All relevant data (age, gender, nature and location of pathology, details of the surgical procedure, implants used, duration of antibiotic treatment, preoperative radiation therapy, hospital stay and time to a dry surgical wound) were collected from the patient files. The primary indication for surgical treatment in the 86 patients (mean age=64 years, M/F = 40/46), included in our study, was de-facto pathological fracture (n=48), impending pathological fracture (n=29) and bone sarcoma (n=9) of the proximal femur (Table 1). In 12 patients (14%), substantial concurrent lesions of the acetabulum or the distal femur were present, requiring a more extensive surgical procedure, either acetabular reconstruction with a cemented partial pelvic replacement (n=7), (Fig. 1B), or total femur replacement (n=5). Complete data for patient survival and duration of hospital stay was available in all cases and in 83, for wound status and duration of antibiotic treatment. In four patients, who required transfer to local hospital (for social reasons, n=3) or another department within our hospital (for treatment of a cerebral abscess, n =1), in spite of modest continued wound drainage, we considered the wound dry and antibiotics discontinued on the day of discharge from our unit, to avoid inadequate overestimation of these parameters. Despite multiple operative wound revisions for continuous drainage, one patient progressed to chronic infection and was ultimately discharged to hospice on post-op day 43 on long-term antibiotics with a draining sinus. In eight cases antibiotics had to be continued after the surgical wound was dry, due to other causes: infection in the chest (n=3), gastrointestinal tract (n=2), urinary tract (n=1), brain (n=1) and one unknown primary focus. In these, antibiotics were considered discontinued the same day as the surgical wound was dry. The study was approved by the Danish Data Protection Agency (no. 2013-412591), but approval from an Ethics Committee is neither possible, nor required in our country for studies based on review of medical records only.

Table 1

Demographics and pathology of all patients treated with tumor resection and endoprosthetic reconstruction of the hip between 2010 and 2012.




Fig. (1)

A: Conventional neck resection (for a pathological femoral head fracture), reconstructed with a full length (350mm), cemented standard stem (Link SPII), to bridge metastatic involvement of the distal femur. Note screw fixation and cement augmentation for a partially healed pathological fracture in the superior acetabular rim. B: Conventional calcar resection (for a pathological femoral neck fracture) and reconstruction of the proximal femur with a cemented modular revision prosthesis (Link MP). Note reconstruction and cement augmentation of a large concurrent acetabular lesion with a pelvic reconstruction cage (Link Partial Pelvic Replacement). C: Proximal femur resection (15cm), reconstructed with a long, cemented mega-prosthesis (Zimmer Segmental System) and a cemented (Link Lubinus Eccentric) acetabular component. Note screw fixation of a polyethylene anti luxation device.



Surgical Procedure and Post-Operative Routine

A routine posterior approach to the hip was employed in all patients. In 38 patients confinement of the tumor to the femoral head or neck allowed a conventional neck resection, preservation of the abductor mechanism and endoprosthetic reconstruction with a cemented standard stem (Biomet Bimetric (n=13)) or a long (200 mm or longer) cemented standard stem (Link SP2 (n=17), or Zimmer CPT (n=1)) (Fig. 1A). The remaining 45 patients required an extended posterior approach, to accommodate the necessary proximal femoral resection (mean resection length 124mm (54-220mm)) and endoprosthetic reconstruction with either a modular revision stem (Link MP (n=33) and Zimmer ZMR (n=1)) (Fig. 1B) or a tumor megaprosthesis (Zimmer Segmental (n=8), Stryker GRMS (n=6), Link Mega C (n=3)) (Fig. 1C). All stems were cemented with the exception of the GMRS stems (short fluted with proximal HA coating), which were used in the youngest patient group after resection of primary bone sarcomas. On the acetabular side, with exception of seven multipolar hemiarthroplasties, the majority of patients received a cemented acetabular component (Lubinus Excentric, (n=75)), or an uncemented cup (Stryker MDM (n=2), Zimmer Trilogy (n=2)). Seven cases required additional peri-acetabular tumor removal and pelvic reconstruction with a cemented pelvic reconstruction ring (Link partial pelvis replacement (Fig. 1B) and in 5 cases of metastatic disease involving the entire femur, total femur replacement, Stryker GRMS total femur (n=1) and Link Mega C total femur (n=4) was required. All incisions were closed in a layered fashion over deep drains, after detached musculature had been reattached to the prosthesis, in an attempt to restore the abductor mechanism and cover the entire prosthesis with vital tissue. Postoperatively all patients were mobilized, weight bearing as tolerated, from post-operative day 1. The sterile compressive dressing applied at conclusion of the procedure was left unchanged until day 2 or 3, to coincide with removal of any surgical drains still present. Prophylactic intravenous antibiotics (Cefuroxime 1.5g x 3) were started 15 to 30 minutes prior to incision and not discontinued before a senior member of the surgical team considered the wound dry. Thromboprophylaxis with Tinzaparin 3500-4500 IE x 1 sc. was maintained until the patients were well mobilized, at least until discharge from hospital.

Statistical Analysis

All data are presented as mean with total range, and p values of <0.05 considered significant. We used standard IBM SPSS software (version 19) for the following statistical calculations: linear regression analysis with calculation of the coefficient of determination (R2) for evaluation of the relation between the main variables (time to dry surgical wound, duration of antibiotic treatment and hospitalization), non-parametric tests for un-paired data (Mann-Whitney) for comparison of subgroups, and Kaplan-Meier survival analysis for estimation of overall patient survival. Calculation of 95% confidence intervals for the survival data was done in Microsoft Excel 2010 using Greenwood’s formula for calculation of standard error.

RESULTS

Overall Survival

As an indirect measure for severity of the underlying disease, we performed an analysis of overall patient survival. Ten patients died within the first 30 post- operative days and probability of overall survival was 74% at 3 months, 63% at 6 months and 45% at 1 year (Fig. 2), indicating that most patients were in advanced stages of their underlying disease.

Fig. (2)

Kaplan Meier survival analysis showing cumulative survival rate (solid line) and 95% confidence interval (dotted lines) for all patients (n=86), who had an endoprosthetic reconstruction of the hip and proximal femur for malignant bone disease between 2010 and 2012.



Prevalence of Prolonged Wound Drainage

Prolonged wound drainage of 7 days or more was observed in 41 cases (48%), and on average, the surgical wound was dry after a mean of 8.4 days (3-24 days), (Fig. 3). When focusing on selected subgroups, we found an even longer duration of PWD in patients with total femur replacement (p=0.005), a primary diagnosis of bone sarcoma (p=0.047) and in patients who required additional pelvic reconstruction (p=0.058). We found no association of wound drainage with overall survival, the extent of the proximal femoral resection or whether the patients had received preoperative radiotherapy or not (Table 2).

Table 2.

Specific analysis of duration of wound drainage of relevant patient subgroups.




Fig. (3)

Patient distribution with regard to the day of dry surgical wound, the length of antibiotic treatment, and the length of admission.



Duration of Antibiotic Prophylaxis and Hospital Stay

Prophylactic antibiotics were administered for an average of 8.7 days (3-28 days) and mean length of hospital stay was 10.2 days (3-44 days) (Fig. 3). Linear regression analysis showed a highly significant relation of wound drainage with the duration of antibiotic treatment (p<0.0005, R2=97%) and the length of hospital stay (p<0.0005, R2=74%).

DISCUSSION

The prevalence of PWD after malignant bone tumor resection and endoprosthetic reconstruction of the proximal femur has not been specifically determined previously. We found a surprisingly high rate and duration of PWD, involving almost every other patient in our cohort. Given the substantial increase in infection risk of 42% with each day of persistent wound drainage, reported by Patel et al. [5Patel VP, Walsh M, Sehgal B, Preston C, DeWal H, Di Cesare PE. Factors associated with prolonged wound drainage after primary hip and knee arthroplasty J Bone Joint Surg Am 2007; 89(1): 33-8.] for conventional THA, a PWD over 7 days, observed in 48% of our patients, could reasonably be expected to further increase the already elevated risk for PJI in this patient population. Not surprisingly, we were able to demonstrate a significant correlation of PWD with duration of antibiotic prophylaxis and length of hospital stay, which indicates that each occurrence of this, obviously not so infrequent complication, directly resulted in increased cost of treatment, even if later infection was prevented.

Compared to conventional arthroplasty, the considerably higher rate of PWD observed in our study, can likely be attributed to a combination of multiple factors. Increasing extent and complexity of the surgical procedure, with larger areas of soft tissue dissection, bone resection, implant dimension, increased blood loss and prolonged operating time, may well explain why total femur replacement, additional pelvic reconstruction and resection of a primary bone sarcoma showed a higher prevalence and duration of PWD. However, these factors were apparently not relevant enough, to lead to a detectable difference between the groups receiving a proximal femur resection compared to a standard resection of the femoral neck in our relatively small patient cohort.

Undoubtedly, patients undergoing tumor arthroplasty exhibit a substantially higher profile of recognized risk factors, compared to routine arthroplasty patients, due to the burden of the primary disease, its associated co-morbidities, such as malnutrition [11Jaberi FM, Parvizi J, Haytmanek CT, Joshi A, Purtill J. Procrastination of wound drainage and malnutrition affect the outcome of joint arthroplasty Clin Orthop Relat Res 2008; 466(6): 1368-71.,12Lavernia CJ, Sierra RJ, Baerga L. Nutritional parameters and short term outcome in arthroplasty J Am Coll Nutr 1999; 18(3): 274-8.], immunosuppression [13 Berbari EF, Osmon DR, Lahr B , et al. The Mayo prosthetic joint infection risk score implication for surgical site infection reporting and risk stratification Infect Control Hosp Epidemiol 2012; 33(8): 774-81.,14Peersman G, Laskin R, Davis J, Peterson M. Infection in total knee replacement a retrospective review of 6489 total knee replacements Clin Orthop Relat Res 2001; (392): 15-23.], impaired renal or liver function and prior and on-going chemotherapy and/or radiotherapy. However, the impact of these factors on our relatively small sample was not significant enough to demonstrate an association between postoperative survival and PWD, even though a higher degree of co-morbidities and severity of disease might have been expected in patients with shorter postoperative survival.

Furthermore, the ultimate manifestation of an actual PJI is of course directly dependent on the quantity and virulence of bacteria that reach and colonize the operative site and the efficacy of preventive measures (or lack thereof). There is wide disparity of practice with regard to type of prophylactic antibiotic as well as length of its administration and there is insufficient evidence for firm recommendations. Despite this lack of sufficient evidence, reportedly high infection rates of up to 35%, even higher reinfection rates as high as 43% [15Musculoskeletal Tumor Society. International Consensus on Periprosthetic Joint Infection. Aug 2013 http://www.msisna.org/wp-content/themes/msis-temp/pdf/ism-periprosthetic-jointinformation.pdf 2013.] and the often dire consequences of PJI resulting in amputation in up to 35% in some series [3Jeys L, Grimer R. The long-term risks of infection and amputation with limb salvage surgery using endoprostheses Recent Results Cancer Res 2009; 179: 75-84.], a recent multinational consensus meeting on PJI (led by the Musculoskeletal Infection Society and the European Bone and Joint Infection Society), recommended the use of routine antibiotic prophylaxis not exceeding 24h, for patients undergoing major reconstruction with mega-prosthesis [15Musculoskeletal Tumor Society. International Consensus on Periprosthetic Joint Infection. Aug 2013 http://www.msisna.org/wp-content/themes/msis-temp/pdf/ism-periprosthetic-jointinformation.pdf 2013.]. A position statement published on the Musculoskeletal Tumor Society (MSTS) website appears to express the opposite opinion, acknowledging the unique antibiotic requirements of tumor patients, potential for unacceptable adverse outcomes and costs associated with treatment of an infected limb salvage joint replacement. They explicitly discourage routine application of standard prophylactic measures to patients with bone and soft-tissue tumors undergoing limb salvage surgery. Instead, they recommend that musculoskeletal oncologists should be supported in their clinical judgment with regards to choice of adequate type and length of post-operative antibiotic prophylaxis for their tumor patients on an individual basis [16Musculoskeletal Tumor Society. Position Statement http: //msts. org/aboutMSTS/positionStatement.html [Assessed on Nov 11 2013];]. Definitive high level evidence to resolve this controversy will probably not become available for many years, as a randomized, controlled, international multicenter trial, to determine the role of long term antibiotics in patients undergoing surgical excision and endoprosthetic reconstruction of a primary bone tumor, has only recently started enrolment of an anticipated total of 920 patients [17Ghert M, Deheshi B, Holt G , et al. Prophylactic antibiotic regimens in tumour surgery(PARITY): protocol for a multicentre randomised controlled study BMJ Open 2012; 2(6): e002197.]. Meanwhile, a recent systematic review of 48 studies including a total of 4838 adult patients having undergone long bone tumor resection and endoprosthetic reconstruction, reported significant reduction in pooled infection rates with long term postoperative antibiotic prophylaxis [1Racano A, Pazionis T, Farrokhyar F, Dehesi B, Ghert M. High infection rate outcomes in long-bone tumor surgery with endoprosthetic reconstruction in adults a systematic review Clin Orthop Relat Res 2013; 471(6): 2017-7.], which supports our current practice. Due to consistent use of extended antibiotic prophylaxis, the infection rate in this high risk population has remained very low at our institution, for over a decade and while it may appear tempting to push for ever shorter durations of hospital stay and antibiotic prophylaxis, short sighted attempts to capitalize on immediate cost savings may well not be of long term benefit to either patient or health economy. Undoubtedly, a reduction of PWD is desirable and should diminish the risk for PJI, as well as the need for prolonged use of prophylactic antibiotics and hospitalization in a highly specialized ward. However, although strategies to reduce PWD should be sought and investigated, their implementation should be carefully monitored, to avoid interference with the potentially beneficial effect of long term prophylactic antibiotics.

We recognize the limitations of our study, inherent to retrospective data collection in general. In particular, we acknowledge some degree of uncertainty about the exact day the surgical wound was considered dry, as the surgical wounds were not inspected daily and neither precise quantification of significant drainage, nor an exact definition of what constituted a dry surgical wound were used. From the wide range of definitions of persistent or prolonged wound drainage used in the literature, we have decided to use and report the most conservative PWD of 7 days or longer, which would be considered abnormal by most orthopedic surgeons. As such, we consider our results sufficient to demonstrate the existence and the scope of an obvious problem and to indicate a need for raised awareness and efforts to identify, develop and implement effective preventive and therapeutic measures to prevent this complication.

CONCLUSION

Prolonged wound drainage (PWD) may be significantly more prevalent in patients undergoing endoprosthetic reconstruction of the hip for malignant bone disease involving the proximal femur, than reports suggest for conventional hip arthroplasty. This may increase the already substantially elevated risk profile of this patient population even further. The occurrence of this complication may prompt prolonged administration of antibiotic prophylaxis, prolonged hospital stay or even revision surgery. Total femur resection, bone sarcoma and pelvic reconstruction were found to be significant independent risk factors for even further persistence of PWD. Given the potentially increased risk for PJI in particular, increased awareness of this complication is recommended and further research directed at identification and implementation of adequate strategies for its prevention and treatment is warranted.

CONFLICT OF INTEREST

The authors declare that there is no conflict of interest related to the content of this article.

ACKNOWLEDGEMENTS

Declared none.

REFERENCES

[1] Racano A, Pazionis T, Farrokhyar F, Dehesi B, Ghert M. High infection rate outcomes in long-bone tumor surgery with endoprosthetic reconstruction in adults a systematic review Clin Orthop Relat Res 2013; 471(6): 2017-7.
[2] Jeys LM, Grimer RJ, Carter SR, Tillman RM. Periprosthetic infection in patients for an orthopaedic oncological condition J Bone Joint Surg Am 2005; 87(4): 842-9.
[3] Jeys L, Grimer R. The long-term risks of infection and amputation with limb salvage surgery using endoprostheses Recent Results Cancer Res 2009; 179: 75-84.
[4] Hernández-Vaquero D, Fernández-Fairen M, Torres A , et al. Treatment of perioprosthetic infections an economic analysis Scientific World Journal 2013; 2013: 821650.
[5] Patel VP, Walsh M, Sehgal B, Preston C, DeWal H, Di Cesare PE. Factors associated with prolonged wound drainage after primary hip and knee arthroplasty J Bone Joint Surg Am 2007; 89(1): 33-8.
[6] Saleh K, Olson M, Resig S , et al. Predictors of wound infection in hip and knee joint replacement results from a 20 year surveillance program J Orthop Res 2002; 20(3): 506-15.
[7] Cordero-Ampuero J, de Dios M. What are the risk factors for infection in hemiarthroplasties and total hip arthroplasties Clin Orthop Relat Res 2010; 468(12): 3268-77.
[8] Eveillard M, Mertl P, Canarelli B , et al. Risk of deep infection in first-intention total hip replacement Evaluation concerning a continuous series of 790 cases Presse Med 2001; 30(38): 1868-75.
[9] Surin VV, Sundholm K, Backman L. Infection after total hip replacement with a special reference to discharge from the wound J Bone Joint Surg Br 1983; 65(4): 412-18.
[10] Jaberi MF, Eslampour A, Haytmanek CT, Parvizi J, Ghanem E, Purtill J. Persistent surgical wound drainage after total hip and knee arthroplasty – Risk factors and final outcome J Bone Joint Surg Br 2009; 91(12): SUPP II- 298.
[11] Jaberi FM, Parvizi J, Haytmanek CT, Joshi A, Purtill J. Procrastination of wound drainage and malnutrition affect the outcome of joint arthroplasty Clin Orthop Relat Res 2008; 466(6): 1368-71.
[12] Lavernia CJ, Sierra RJ, Baerga L. Nutritional parameters and short term outcome in arthroplasty J Am Coll Nutr 1999; 18(3): 274-8.
[13] Berbari EF, Osmon DR, Lahr B , et al. The Mayo prosthetic joint infection risk score implication for surgical site infection reporting and risk stratification Infect Control Hosp Epidemiol 2012; 33(8): 774-81.
[14] Peersman G, Laskin R, Davis J, Peterson M. Infection in total knee replacement a retrospective review of 6489 total knee replacements Clin Orthop Relat Res 2001; (392): 15-23.
[15] Musculoskeletal Tumor Society. International Consensus on Periprosthetic Joint Infection. Aug 2013 http://www.msisna.org/wp-content/themes/msis-temp/pdf/ism-periprosthetic-jointinformation.pdf 2013.
[16] Musculoskeletal Tumor Society. Position Statement http: //msts. org/aboutMSTS/positionStatement.html [Assessed on Nov 11 2013];
[17] Ghert M, Deheshi B, Holt G , et al. Prophylactic antibiotic regimens in tumour surgery(PARITY): protocol for a multicentre randomised controlled study BMJ Open 2012; 2(6): e002197.

Endorsements



"Open access will revolutionize 21st century knowledge work and accelerate the diffusion of ideas and evidence that support just in time learning and the evolution of thinking in a number of disciplines."


Daniel Pesut
(Indiana University School of Nursing, USA)

"It is important that students and researchers from all over the world can have easy access to relevant, high-standard and timely scientific information. This is exactly what Open Access Journals provide and this is the reason why I support this endeavor."


Jacques Descotes
(Centre Antipoison-Centre de Pharmacovigilance, France)

"Publishing research articles is the key for future scientific progress. Open Access publishing is therefore of utmost importance for wider dissemination of information, and will help serving the best interest of the scientific community."


Patrice Talaga
(UCB S.A., Belgium)

"Open access journals are a novel concept in the medical literature. They offer accessible information to a wide variety of individuals, including physicians, medical students, clinical investigators, and the general public. They are an outstanding source of medical and scientific information."


Jeffrey M. Weinberg
(St. Luke's-Roosevelt Hospital Center, USA)

"Open access journals are extremely useful for graduate students, investigators and all other interested persons to read important scientific articles and subscribe scientific journals. Indeed, the research articles span a wide range of area and of high quality. This is specially a must for researchers belonging to institutions with limited library facility and funding to subscribe scientific journals."


Debomoy K. Lahiri
(Indiana University School of Medicine, USA)

"Open access journals represent a major break-through in publishing. They provide easy access to the latest research on a wide variety of issues. Relevant and timely articles are made available in a fraction of the time taken by more conventional publishers. Articles are of uniformly high quality and written by the world's leading authorities."


Robert Looney
(Naval Postgraduate School, USA)

"Open access journals have transformed the way scientific data is published and disseminated: particularly, whilst ensuring a high quality standard and transparency in the editorial process, they have increased the access to the scientific literature by those researchers that have limited library support or that are working on small budgets."


Richard Reithinger
(Westat, USA)

"Not only do open access journals greatly improve the access to high quality information for scientists in the developing world, it also provides extra exposure for our papers."


J. Ferwerda
(University of Oxford, UK)

"Open Access 'Chemistry' Journals allow the dissemination of knowledge at your finger tips without paying for the scientific content."


Sean L. Kitson
(Almac Sciences, Northern Ireland)

"In principle, all scientific journals should have open access, as should be science itself. Open access journals are very helpful for students, researchers and the general public including people from institutions which do not have library or cannot afford to subscribe scientific journals. The articles are high standard and cover a wide area."


Hubert Wolterbeek
(Delft University of Technology, The Netherlands)

"The widest possible diffusion of information is critical for the advancement of science. In this perspective, open access journals are instrumental in fostering researches and achievements."


Alessandro Laviano
(Sapienza - University of Rome, Italy)

"Open access journals are very useful for all scientists as they can have quick information in the different fields of science."


Philippe Hernigou
(Paris University, France)

"There are many scientists who can not afford the rather expensive subscriptions to scientific journals. Open access journals offer a good alternative for free access to good quality scientific information."


Fidel Toldrá
(Instituto de Agroquimica y Tecnologia de Alimentos, Spain)

"Open access journals have become a fundamental tool for students, researchers, patients and the general public. Many people from institutions which do not have library or cannot afford to subscribe scientific journals benefit of them on a daily basis. The articles are among the best and cover most scientific areas."


M. Bendandi
(University Clinic of Navarre, Spain)

"These journals provide researchers with a platform for rapid, open access scientific communication. The articles are of high quality and broad scope."


Peter Chiba
(University of Vienna, Austria)

"Open access journals are probably one of the most important contributions to promote and diffuse science worldwide."


Jaime Sampaio
(University of Trás-os-Montes e Alto Douro, Portugal)

"Open access journals make up a new and rather revolutionary way to scientific publication. This option opens several quite interesting possibilities to disseminate openly and freely new knowledge and even to facilitate interpersonal communication among scientists."


Eduardo A. Castro
(INIFTA, Argentina)

"Open access journals are freely available online throughout the world, for you to read, download, copy, distribute, and use. The articles published in the open access journals are high quality and cover a wide range of fields."


Kenji Hashimoto
(Chiba University, Japan)

"Open Access journals offer an innovative and efficient way of publication for academics and professionals in a wide range of disciplines. The papers published are of high quality after rigorous peer review and they are Indexed in: major international databases. I read Open Access journals to keep abreast of the recent development in my field of study."


Daniel Shek
(Chinese University of Hong Kong, Hong Kong)

"It is a modern trend for publishers to establish open access journals. Researchers, faculty members, and students will be greatly benefited by the new journals of Bentham Science Publishers Ltd. in this category."


Jih Ru Hwu
(National Central University, Taiwan)


Browse Contents



Webmaster Contact: info@benthamopen.net
Copyright © 2019 Bentham Open