|
SWITCH REGIMEN N=610 (24.8%) N(%) or Median(IQR) |
NO SWITCH REGIMEN N=1847 (75.2%) N(%) or Median(IQR) |
UNIVARIATE ODDS RATIO (95% CI) |
P- VALUE |
|
|---|---|---|---|---|
| Medical Illnesses | ||||
| Cerebrovascular Disease | 6 (1.0%) | 9 (0.5%) | 2.03 (0.72,5.73) | 0.1806 |
| Chronic Obstructive Pulmonary Disease | 11 (1.8%) | 16 (0.9%) | 2.10 (0.97,4.56) | 0.0594 |
| Chronic Viral Hepatitis Disease | 80 (13.1%) | 194 (10.5%) | 1.29 (0.97,1.70) | 0.0762 |
| Cirrhosis | 5 (0.8%) | 20 (1.1%) | 0.76 (0.28,2.02) | 0.5758 |
| Coronary Artery Disease | 22 (3.6%) | 49 (2.7%) | 1.37 (0.82,2.29) | 0.2245 |
| Diabetes Mellitus | 68 (11.1%) | 133 (7.2%) | 1.62 (1.19,2.20) | 0.0022 |
| Malignancy other than Basal Cell Carcinoma | 100 (16.4%) | 173 (9.4%) | 1.90 (1.46,2.47) | <.0001 |
| Tuberculosis other than latent infection | 12 (2.0%) | 25 (1.4%) | 1.46 (0.73,2.93) | 0.2831 |
| Mental Health Illnesses | ||||
| Anxiety Disorder | 71 (11.6%) | 144 (7.8%) | 1.56 (1.15,2.10) | 0.0038 |
| Bipolar Disorder | 21 (3.4%) | 27 (1.5%) | 2.41 (1.35,4.29) | 0.0029 |
| Major Depression | 196 (32.1%) | 398 (21.5%) | 1.72 (1.41,2.11) | <.0001 |
| Post-Traumatic Stress Disorder | 11 (1.8%) | 26 (1.4%) | 1.29 (0.63,2.62) | 0.4877 |
| Prior Suicide Attempt | 10 (1.6%) | 13 (0.7%) | 2.35 (1.03,5.39) | 0.0431 |
| Substance Abuse | 85 (13.9%) | 198 (10.7%) | 1.35 (1.03,1.77) | 0.0315 |
| Serum Levels at Initiation | ||||
| ALT(U/L) | 33.5 (26) | 32 (23) | 1.00 (1.00,1.00) | 0.1366 |
| AST(U/L) | 31 (17) | 29 (15) | 1.00 (1.00,1.00) | 0.0945 |
| Total Bilirubin (mg/dL) | 0.6 (0.35) | 0.6 (0.4) | 1.25 (1.03,1.51) | 0.0207 |
| HDL (mg/dL) | 37 (15) | 39 (15) | 0.97 (0.96,0.99) | 0.0007 |
| LDL (mg/dL) | 97 (38) | 101 (41) | 1.00 (0.99,1.00) | 0.1451 |
| Triglycerides (mg/dL) | 133 (122) | 110 (92) | 1.00 (1.00,1.00) | 0.0927 |
| Glucose (mg/dL) | 87 (20) | 87 (16) | 1.00 (1.00,1.01) | 0.4271 |
| Creatinine (mg/dL) | 1 (0.2) | 1 (0.2) | 0.79 (0.50,1.24) | 0.3023 |
| Hemoglobin(g/dL) | 14 (2.1) | 14.4 (1.7) | 0.85 (0.79,0.91) | <.0001 |