Table 3: Infections, Vaccinations and/or Trauma Experienced (Ever) Prior to Diagnosis, or One-Year Prior to Diagnosis of SSc/Non-Inflammatory MSK Disorder. Given as Percentage (N).

Infection(s) Ever Prior to Diagnosis Scleroderma % (N) Controls % (N) p-value OR Scl vs. controls 95 % CI
Bacterial infections 68 (59) 78 (177) 0.1 0.59 (0.31,1.14)
Hepatitis A 1.6 (62) 3 (186) 0.6 0.59 (0.07,5.18)
Hepatitis B 1.6 (62) 0 (186) 0.08 - -
Hepatitis C 1.6 (62) 2 (186) 0.8 0.74 (0.08,6.80)
Herpes zoster 12 (60) 8 (192) 0.4 1.45 (0.57,3.72)
Parvovirus 1.6 (62) 0 (186) 0.2 - -
Rheumatic fever 8 (62) 7 (186) 0.8 1.17 (0.40,3.40)
Rubella 51 (49) 58 (144) 0.5 0.76 (0.40,1.47)
Tuberculosis skin test 8 (64) 13 (188) 0.2 0.55 (0.20,1.51)
Vaccinations 49 (59) 50 (189) 0.9 0.95 (0.53,1.72)
Trauma prior 19 (64) 44 (195) 0.0003 0.30 (0.15,1.59)
Infections 1-Year Prior to Diagnosis Scleroderma % (N) Controls % (N) p-value OR Scl vs. controls 95% CI
Any infection 16 (51) 35 (163) 0.006 0.34 (0.15,0.78)
Streptococcal throat infection 8 (53) 13 (157) 0.3 0.53 (0.17,1.62)
Antibiotic use 34 (35) 50 (111) 0.09 0.51 (0.23,1.13)

Please note: the total number of subjects (N) who responded to each question was variable, as subjects may have skipped questions for which they were uncertain, and if they indicated that they were unsure, they were excluded from the analysis for that item.