Table 1: Differentially expressed genes in PC-treated via untreated OA chondrocytes.

Biological
process
Gene ID Gene
Identifier
Fold
change*
Description
Cell proliferation
HELLS NM_018063 -2.32 Helicase, lymphoid-specific
NDP NM_000266 -2.30 Norrie disease (pseudoglioma)
EREG NM_001432 -2.18 Epiregulin
KIF15 NM_020242 -1.98 Kinesin family member 15
SPRY2 NM_005842 -1.92 Sprouty homolog 2 (Drosophila)
ENPP7 AA701973 -1.91 Ectonucleotide pyrophosphatase/phosphodiesterase 7
E2F7 AI341146 -1.87 E2F transcription factor 7
IL7 NM_000880 -1.82 Interleukin 7
UHRF1 AK025578 -1.78 Ubiquitin-like with PHD and ring finger domains 1
CDK5R1 AL567411 -1.75 Cyclin-dependent kinase 5, regulatory subunit 1 (p35)
TACC3 NM_006342 -1.75 Transforming, acidic coiled-coil containing protein 3
NTN1 BF591483 -1.75 Netrin 1
EEF1E1 N32257 -1.74 Eukaryotic translation elongation factor 1 epsilon 1
TCF19 BC002493 -1.74 Transcription factor 19
GINS1 NM_021067 -1.73 GINS complex subunit 1 (Psf1 homolog)
NR2F2 AL554245 -1.72 Nuclear receptor subfamily 2, group F, member 2
CCND1 BC000076 -1.68 Cyclin D1
SOX4 AI989477 -1.67 SRY (sex determining region Y)-box 4
MEF2C N22468 -1.66 Myocyte enhancer factor 2C
CDKN2D U20498 -1.63 Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
HBEGF NM_001945 -1.62 Heparin-binding EGF-like growth factor
FOSL1 BG251266 -1.58 FOS-like antigen 1
MKI67 AU152107 -1.58 Antigen identified by monoclonal antibody Ki-67
TRIM24 NM_015905 -1.57 Tripartite motif-containing 24
SPHK1 NM_021972 -1.56 Sphingosine kinase 1
BLM NM_000057 -1.55 Bloom syndrome, RecQ helicase-like
BMP2 NM_001200 -1.55 Bone morphogenetic protein 2
ACER3 R12678 -1.55 Alkaline ceramidase 3
CDCA7 AY029179 -1.52 Cell division cycle associated 7
CDC20 NM_001255 -1.50 Cell division cycle 20 homolog (S. cerevisiae)
B4GALT1 M22921 2.20 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
FGFR2 M80634 1.99 Fibroblast growth factor receptor 2
EGR1 AI459194 1.98 Early growth response 1
TXNIP AA812232 1.82 Thioredoxin interacting protein
TGFBR1 AV700621 1.74 Transforming growth factor, beta receptor 1
DDR2 AA545764 1.58 Discoidin domain receptor tyrosine kinase 2
CSF1 U22386 1.55 Colony stimulating factor 1 (macrophage)
IGFBP5 R73554 1.53 Insulin-like growth factor binding protein 5
ARIH2 AW074830 1.51 Ariadne homolog 2 (Drosophila)
Apoptosis
HELLS NM_018063 -2.32 Helicase, lymphoid-specific
DUSP6 BC003143 -2.30 Dual specificity phosphatase 6
SPRY2 NM_005842 -1.92 Sprouty homolog 2 (Drosophila)
PCGF2 NM_007144 -1.89 Polycomb group ring finger 2
IL7 NM_000880 -1.82 Interleukin 7
BIRC5 AA648913 -1.76 Baculoviral IAP repeat-containing 5
CDK5R1 AL567411 -1.75 Cyclin-dependent kinase 5, regulatory subunit 1 (p35)
RASSF5 BC004270 -1.75 Ras association (RalGDS/AF-6) domain family member 5
NTN1 BF591483 -1.75 Netrin 1
EEF1E1 N32257 -1.74 Eukaryotic translation elongation factor 1 epsilon 1
PAK1 AU147145 -1.73 P21 protein (Cdc42/Rac)-activated kinase 1
BCAP29 AL583687 -1.72 B-cell receptor-associated protein 29
LMNB1 NM_005573 1.70 Lamin B1
EPHA2 NM_004431 -1.69 EPH receptor A2
PHLDA1 AK026181 -1.68 Pleckstrin homology-like domain, family A, member 1
ALDH1A3 NM_000693 -1.67 Aldehyde dehydrogenase 1 family, member A3
ALKBH1 AI922200 -1.67 AlkB, alkylation repair homolog 1 (E. coli)
SOX4 AI989477 -1.67 SRY (sex determining region Y)-box 4
MEF2C N22468 -1.66 Myocyte enhancer factor 2C
RNF130 AL831873 -1.64 Ring finger protein 130
CDKN2D U20498 -1.63 Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
FOSL1 BG251266 -1.58 FOS-like antigen 1
TRIM24 NM_015905 -1.57 Tripartite motif-containing 24
SPHK1 NM_021972 -1.56 Sphingosine kinase 1
BMP2 NM_001200 -1.55 Bone morphogenetic protein 2
CDC2 AL524035 -1.54 Cell division cycle 2, G1 to S and G2 to M
CRADD U79115 -1.53 CASP2 and RIPK1 domain containing adaptor with death domain
EXPL1 D79987 -1.53 extra spindle pole bodies homolog 1 (S. cerevisiae)
PHLDA1 NM_007350 -1.52 Pleckstrin homology-like domain, family A, member 1
MAP1S NM_018174 -1.52 Microtubule-associated protein 1S
MCL1 BF594446 2.33 Myeloid cell leukemia sequence 1 (BCL2-related)
B4GALT1 M22921 2.20 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
MX1 NM_002462 2.02 Myxovirus resistance 1, interferon-inducible protein p78 (mouse)
FGFR2 M80634 1.99 Fibroblast growth factor receptor 2
TXNIP AA812232 1.82 Thioredoxin interacting protein
TGFBR1 AV700621 1.74 Transforming growth factor, beta receptor 1
ARRB2 NM_004313 1.61 Arrestin, beta 2
SMAD3 BF971416 1.55 SMAD family member 3
TGF-β receptor signaling pathway
TGFBR1 AV700621 1.74 Transforming growth factor, beta receptor 1
ARRB2 NM_004313 1.61 Arrestin, beta 2
C5orf13 U36189 1.59 Chromosome 5 open reading frame 13
SMURF1 AC004893 1.57 SMAD specific E3 ubiquitin protein ligase 1
SMAD3 BF971416 1.55 SMAD family member 3
Ossification
FGFR2 M80634 1.99 Fibroblast growth factor receptor 2
RSAD2 AW189843 1.63 Radical S-adenosyl methionine domain containing 2
PDLIM7 AW206786 1.57 PDZ and LIM domain 7 (enigma)
SMURF1 AC004893 1.57 SMAD specific E3 ubiquitin protein ligase 1
IGFBP5 R73554 1.53 Insulin-like growth factor binding protein 5
ENPP1 BF057080 -1.66 Ectonucleotide pyrophosphatase/phosphodiesterase 1
BMP2 NM_001200 -1.55 Bone morphogenetic protein 2

*Negative number indicates decreased expression and positive number indicates increased expression (fold change) in PC-treated OA chondrocytes compared with untreated OA chondrocytes.