|
RA Patients n (%) |
Controls n (%) |
Statistical Analyses | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
Total (n=81) |
ACPA+ (n=51) |
ACPA- (n=30) |
(n=40) |
Patients vs controls |
ACPA+ pts vs controls |
ACPA- pts vs controls |
ACPA+ pts vs ACPA- pts vs controls |
ACPA+ pts vs ACPA- pts |
ACPA+ GG/TT pts vs ACPA- GG/TT pts |
|
| STAT4 rs7574865 alleles | ||||||||||
| Subjects with G allele(s) | 75 (92.6%) |
45 (88.2%) |
30 (100%) |
36 (90%) |
p=.628 (MWW) | p=.790 (MWW) | p=.077 (MWW) | p=.161 (K-W) | p=.052 (MWW) | p=.045 (MWW) τ=.278, p=.045 |
| Subjects with T allele(s) | 35 (43.2%) |
25 (49%) |
10 (33.3%) |
15 (37.5%) |
p=.550 (MWW) | p=.274 (MWW) | p=.721 (MWW) | p=.323 (K-W) | p=.171 (MWW) | p=.029 (MWW) τ=.304, p=.029 |
| G allele frequency | 121 (74.7%) |
71 (69.6%) |
50 (83.3%) |
61 (76.3%) |
p=.670 (MWW) | p=.311 (MWW) | p=.525 (MWW) | p=.233 (K-W) | p=.095 (MWW) | p=.029 (MWW) τ=.301, p=.029 |
| T allele frequency | 41 (25.3%) |
31 (30.4%) |
10 (16.7%) |
19 (23.8%) |
p=.670 (MWW) | p=.311 (MWW) | p=.525 (MWW) | p=.233 (K-W) | p=.095 (MWW) | p=.029 (MWW) τ=.301, p=.029 |
| STAT4 rs7574865 genotypes | ||||||||||
| GG | 46 (56.8%) |
26 (51%) |
20 (66.7%) |
25 (62.5%) |
p=.754 (MWW) | p=.392 (MWW) | p=.525 (MWW) | p=.310 (K-W) | p=.131 (MWW) | p=.045 (MWW) τ=.278, p=.045 |
| GT | 29 (35.8%) |
19 (37.3%) |
10 (33.3%) |
11 (27.5%) |
||||||
| TT | 6 (7.4%) |
6 (11.8%) |
0 (0%) |
4 (10%) |
||||||