Table 1: Comparison of Patient Characteristics at Index Dates Between Study 2 vs Study 1 Cohorts Using Logistic Regression Models

Acetaminophen Naproxen
Study 1 Study 2 OR (95% CI) Study 1 Study2 OR (95% CI)
Total No. of patients 205,238 193,918 - 35,330 19,884 -
Female%
Age at index date (± SD)		 62.7
76.5 ± 7.1		 62.0
77.0 ± 7.2		 0.95 (0.94, 0.96)
1.01 (1.01, 1.01)		 57.6
72.8 ± 5.7		 52.8
72.5 ± 5.6		 0.84 (0.81, 0.88)
0.99 (0.99, 1.00)
NSAIDs in prior year 13.7 3.8 0.26 (0.25, 0.27) 36.4 22.4 0.54 (0.52, 0.56)
GI test in prior year %
   Peptic ulcer disease
   GPA in prior year
   PPI
   H2-RA
   Misoprostol
GPA at index date %
   PPI
   H2-RA
   Misoprostol		 9.8
2.3

18.7
12.5
1.0

5.0
2.8
0.1		 8.6
1.9

29.4
5.7
0.2

9.8
1.4
0.0		 0.75 (0.74, 0.77)
0.79 (0.75, 0.83)

1.86 (1.83, 1.90)
0.45 (0.44, 0.46)
0.31 (0.27, 0.35)

1.50 (1.46, 1.54)
1.00 (0.95, 1.06)
0.83 (0.58, 1.20)		 5.2
1.2

11.8
8.5
2.3

6.1
2.3
2.6		 4.2
0.7

18.3
3.7
0.5

11.6
1.2
0.5		 0.71 (0.65, 0.78)
0.62 (0.51, 0.76)

1.93 (1.82, 2.03)
0.47 (0.43, 0.51)
0.48 (0.39, 0.60)

1.75 (1.64, 1.87)
0.88 (0.76, 1.03)
0.28 (0.23, 0.35)
Comorbidities%
   Anemia blood disease
   Renal failure (acute/chronic)
   COPD
   Osteoarthritis
   Rheumatoid arthritis
8.0
2.6
10.5
14.4
1.6
8.7
3.5
8.9
13.9
1.5
1.05 (1.03, 1.08)
1.15 (1.11, 1.20)
0.82 (0.80, 0.84)
1.14 (1.12, 1.16)
1.04 (0.98, 1.10)
4.1
0.9
6.4
17.1
2.7
3.9
1.0
5.0
12.7
2.1
0.97 (0.89, 1.07)
1.00 (0.82, 1.20)
0.76 (0.70, 0.82)
0.81 (0.77, 0.85)
1.03 (0.90, 1.16)
Prior* CV risk %
   CHF
   IHD
   Acute CVD
   PVD
7.3
21.7
3.5
5.1
7.1
22.5
3.7
4.7
0.78 (0.76, 0.80)
0.88 (0.86, 0.89)
0.72 (0.69, 0.74)
0.77 (0.75, 0.80)
2.6
14.0
1.4
2.9
2.0
12.9
1.1
2.4
0.71 (0.62, 0.81)
0.82 (0.77, 0.87)
0.53 (0.44, 0.63)
0.73 (0.65, 0.82)
Prior medication use%
   Antidiabetic
   Antihypertensive
   Lipid lowering agents
   SSRI
   Vasodilator
   Medication use in prior 90 days
   Anticoagulant
   Corticosteroid
   Clopidogrel
Aspirin
9.8
49.6
16.3
6.1
20.6

8.7
6.2
0.7
27.7
17.0
60.0
19.3
5.7
20.1

11.5
6.3
3.9
35.9
1.05 (1.03, 1.07)
1.43 (1.41, 1.45)
1.13 (1.11, 1.15)
0.92 (0.89, 0.94)
0.73 (0.72, 0.74)

1.50 (1.46, 1.53)
1.08 (1.05, 1.11)
6.02 (5.67, 6.40)
1.53 (1.51, 1.55)
10.2
37.7
16.9
3.5
12.1

1.8
4.5
0.2
19.1
11.1
45.2
17.5
2.9
9.8

2.4
4.4
1.3
25.2
0.99 (0.93, 1.05)
1.37 (1.31, 1.42)
0.95 (0.90, 1.00)
0.83 (0.75, 0.92)
0.67 (0.62, 0.72)

1.47 (1.29, 1.68)
1.09 (0.99, 1.20)
7.97 (5.97, 10.64)
1.58 (1.50, 1.65)

* Identified in the prior year.
Abbreviations: GI= gastrointestinal; GPA= gastroprotective agent; PPI= proton pump inhibitor; H2RA= histamine-2 receptor antagonist; SSRI= serotonin reuptake inhibitor; COPD=chronic obstructive pulmonary disease; CHF= congestive heart failure; IHD= ischemic heart disease; CVD= cerebrovascular disease; PVD= peripheral vascular disease; CV= cardiovascular disease; OR= odds ratio; CI= confidence interval; SD= standard deviation.