Discrepancy Among Observational Studies: Example of Naproxen- Associated Adverse Events

Table 4: Association Between Naproxen vs Acetaminophen Utilisation and Hospitalization for GI and AMI Adverse Events- Cox-Regression Models with Time Dependent Exposure

	AMI Hospitalizations		GI Hospitalizations
	Study 1	Study 2	Study 1	Study 2
HR (95% CI)
Acetamin.	1 (reference)	1 (reference)	1 (reference)	1 (reference)
Naproxen	0.94 (0.70,1.25)	1.18 (0.83,1.67)	2.22 (1.62,3.06)	4.94 (3.48,7.02)
Acetamin.+ aspirin	1.10 (0.97,1.26)	1.15 (1.01,1.30)	1.46 (1.20,1.77)	2.31 (1.89, 2.82)
Naproxen + aspirin	1.05 (0.68,1.61)	1.44 (0.95, 2.18)	2.47(1.48,4.12)	4.94 (2.93, 8.33)

The models adjusted for all patient characteristics that appear in Table 1.