Table 1: Preference and Usability Outcomes*

Patient-Reported Outcomes

 Overall preference (primary endpoint)
 “Which of the pre-filled syringes would you prefer from now on?”

 Patient satisfaction
 “How would you assess, in summary, the small/large syringe at the end of the study?”
 Five categories were suggested: “very poor”, “poor”, “no preference”, “good” and “very good”.

 Syringe with or without pre-attached needle
 “How do you like the pre-attached needle (small syringe) in comparison to one that still has to be attached (large syringe)?”
 Five categories were suggested: “great disadvantage”, “disadvantage”, “no difference”, “advantage”, and “great advantage”.

 Usability of syringe volume
 “Do you feel comfortable with the fact that the injection liquid is five times less in the small syringe than in the large syringe?”
 Five possible answers were suggested: “fully disagree”, ”disagree”, ”indifferent”, “agree” and “fully agree”.

 Local tolerability
 Occurrence of erythema, swelling, itching, pain and haematoma assessed as “none”, “mild”, “moderate” or “severe”.

 Usability of the 10 mg/ml syringe at the 2nd and 3rd injection (MC formulation) and of the 50 mg/ml syringe at the 5th and 6th injection (HC formulation)
 Rated on a visual scale from 0 (not convenient = 0 mm) to 10 (very convenient = 100 mm).

Physician-Reported Outcomes

 Usability of the 10 mg/ml syringe at the 1st injection (MC formulation) and of the 50 mg/ml syringe at the 4th injection (HC formulation)
 Rated on a visual scale from 0 (not convenient = 0 mm) to 10 (very convenient = 100 mm).

 Local tolerability
 Occurrence of erythema, swelling, itching, pain and haematoma assessed as “none”, “mild”, “moderate” or “severe”.

Study Nurse/Physician-Reported Outcomes

 Syringe with or without pre-attached needle
 “How do you like the pre-attached needle (small syringe) in comparison to the one which still has to be attached (large syringe)?”
 Five categories were suggested: “great disadvantage”, “disadvantage”, “no difference”, “advantage”, and “great advantage”.

 Usability of syringe volume
 “Do you feel comfortable with the fact that the injection liquid is five times less in the small syringe than in the large syringe?”
 Five possible answers were suggested: “fully disagree”, ”disagree”, ”indifferent”, “agree” and “fully agree”.

 Overall assessment of the small prefilled syringe
 Five categories were suggested: “very poor”, “poor”, “no preference”, “good” and “very good”.

 Overall assessment of the large prefilled syringe
 Five categories were suggested: “very poor”, “poor”, “no preference”, “good” and “very good”.

* Original in German.