Table 1: Clinical Studies Included in the Pooled Analysis

Duration of Treatment Treatment Groups
Osteoarthritis and/or Rheumatoid Arthritis
N49-96-02-012 4 Wks placebo, celecoxib 40 mg BID, celecoxib 200 mg BID, celecoxib 400 mg BID
N49-96-02-020 12 Wks placebo, celecoxib 50 mg BID, celecoxib 100 mg BID, celecoxib 200 mg BID, naproxen 500 mg BID
N49-96-02-021 12 Wks placebo, celecoxib 50 mg BID, celecoxib 100 mg BID, celecoxib 200 mg BID, naproxen 500 mg BID
N49-96-02-022 12 Wks placebo, celecoxib 100 mg BID, celecoxib 200 mg BID, celecoxib 400 mg BID, naproxen 500 mg BID
N49-96-02-023 12 Wks placebo, celecoxib 100 mg BID, celecoxib 200 mg BID, celecoxib 400 mg BID, naproxen 500 mg BID
I49-96-02-041 24 Wks celecoxib 200 mg BID, diclofenac SR 75 mg BID
I49-96-02-042 6 Wks celecoxib 100 mg BID, diclofenac 50 mg BID
N49-96-02-047 4 Wks placebo, celecoxib 25 mg BID, celecoxib 100 mg BID, celecoxib 400 mg BID
N49-96-02-054 12 Wks placebo, celecoxib 50 mg BID, celecoxib 100 mg BID, celecoxib 200 mg BID, naproxen 500 mg BID
N49-96-02-060 6 Wks placebo, celecoxib 100 mg BID, celecoxib 200 mg QD
N49-96-02-062 12 Wks celecoxib 200 mg, naproxen 500 mg BID
N49-96-02-071 12 Wks celecoxib 200 mg BID, diclofenac 75 mg BID, Ibuprofen 800 mg TID
N49-96-02-087 6 Wks placebo, celecoxib 100 mg BID, celecoxib 200 mg QD
I49-96-02-096 12 Wks celecoxib 100 mg BID, celecoxib 200 mg BID, diclofenac 50 mg BID, naproxen 500 mg BID
N49-96-02-035/102 (CLASS trial) Event-driven: median 6-9 months celecoxib 400 mg BID, ibuprofen 800 mg TID, diclofenac 75 BID
I49-96-02-105 12 Wks celecoxib 100 mg BID, diclofenac 50 mg BID
I49-96-02-106 12 Wks celecoxib 100 mg BID, diclofenac 50 mg BID
I49-96-02-107 12 Wks celecoxib 100 mg BID, diclofenac 50 mg BID
N49-96-02-118 6 Wks placebo, celecoxib 100 mg BID, diclofenac 50 mg TID
N49-96-02-149 6 Wks celecoxib 200 mg QD, rofecoxib 25 mg QD
N49-96-02-152 6 Wks celecoxib 200 mg QD, rofecoxib 25 mg QD
N49-96-02-181 6 Wks celecoxib 200 mg QD, rofecoxib 25 mg QD
J49-01-02-216 4 Wks placebo, celecoxib 100 mg BID, loxoprofen 60 mg TID
635-IFL-0508-002 12 Wks celecoxib 200 mg QD, rofecoxib 25 mg QD, naproxen 500 mg BID
635-IFL-0508-003 6 Wks placebo, celecoxib 200 mg QD, rofecoxib 25 mg QD
A3191006 52 Wks celecoxib 200 mg QD, diclofenac 50 mg BID
A3191025 1 yra celecoxib 200 mg QD, diclofenac 50 mg BID
A3191051 6 Wks placebo, celecoxib 200 mg QD, naproxen 500 mg BID
A3191052 6 Wks placebo, celecoxib 200 mg QD, naproxen 500 mg BID
A3191053 6 Wks placebo, celecoxib 200 mg QD, naproxen 500 mg BID
A3191062 6 Wks placebo, celecoxib 200 mg QD, ibuprofen 800 mg TID
A3191063 6 Wks placebo, celecoxib 200 mg QD, ibuprofen 800 mg TID
A3191069 6 Wks placebo, celecoxib 200 mg QD
A3191082 6 Wks placebo, celecoxib 200 mg QD
A3191152 6 Mths celecoxib 200 mg QD, naproxen 500 mg BID
COXA-0508-261 12 Wks celecoxib 200 mg QD, diclofenac 50 mg TID
Ankylosing Spondylitis
F49-98-02-137 6 Wks placebo, celecoxib 100 mg BID, ketoprofen 100 mg BID
N49-01-02-193 12 Wks placebo, celecoxib 200 mg QD, celecoxib 400 mg QD, naproxen 500 mg BID
COXA-0503-243 12 Wks celecoxib 200 mg QD, celecoxib 200 mg BID, diclofenac 75 mg SR BID
COXA-0503-247 12 Wks celecoxib 200 mg QD, celecoxib 400 mg QD, diclofenac 75 mg TID
Chronic Low Back Pain
J49-01-02-217 4 Wks celecoxib 100 mg BID, loxoprofen 60 mg TID
COXA-0508-244 12 Wks placebo, celecoxib 200 mg QD
COXA-0508-245 12 Wks placebo, celecoxib 200 mg QD
COXA-0508-269 12 Wks placebo, celecoxib 200 mg QD, celecoxib 200 mg BID
A3191174 4 Wks celecoxib 200 mg BID, loxoprofen 60 mg TID
Alzheimer Disease
IQ5-97-02-001 52 Wks placebo, celecoxib 200 mg BID
EQ5-98-02-002 3 yra placebo, celecoxib 200 mg BID
NQ5-98-02-005 4 Wks placebo, celecoxib 200 mg BID
Spontaneous Colorectal Adenomatous Polyps
NQ4-00-02-011 12 Wksa placebo, celecoxib 100 mg BID, celecoxib 200 mg BID, celecoxib 400 mg BID
EQ4-00-02-018 3 ya placebo, celecoxib 400 mg QD
IQ4-99-02-005 3ya placebo, celecoxib 200 mg BID, celecoxib 400 mg BID

For this analysis, blood loss was predefined as a decrease in hemoglobin ≥2 g/dL and/or hematocrit ≥10% from baseline.QD: once daily; BID: twice daily; TID: three times daily.
a Treatment with study medication was suspended or terminated early.