Table 4: Secondary Efficacy Outcome Measures Analyses (PP Dataset)

Outcome Structum (N=348) Chondrosulf (N = 344) Difference [95% CI]
Global pain (100 mm VAS) Change baseline - W24 -28.99 (21.94) -29.91 (22.32)
Pain on motion (100 mm VAS) Change baseline - mean over 24 weeks 23.52 (18.00) 23.60 (18.78) -0.086 [-2.83, 2.66]
Pain at rest (100 mm VAS) Change baseline - mean over 24 Weeks 16.23 (20.45) 16.19 (18.89) 0.039 [-2.90, 2.98]
LFI score Change baseline - W24 -4.13 (3.11) -4.10 (3.17)
Patient’s global assessment Change baseline - W24 7.20 (21.11) 5.65 (20.60) 1.550 [-1.60, 4.70]
Investigator’s global assessment Change baseline - W24 6.98 (18.72) 4.72 (18.19) 2.253 [-0.52, 5.03]
SF-12-PCS Change baseline - W24 4.44 (8.67) 5.49 (8.12) -1.053 [-2.40, 0.30]
SF-12-MCS Change baseline - W24 1.66 (9.85) 1.57 (9.74) 0.099 [-1.48, 1.67]
OAKHQOL-Physical Change baseline - W24 11.93 (18.12) 13.32 (16.68) -1.393 [-4.02, 1.23]
OAKHQOL-pain Change baseline - W24 16.71 (21.52) 17.23 (19.97) -0.521 [-3.78, 2.74]
OAKHQOL-Mental health Change baseline - W24 4.34 (16.46) 7.87 (15.09) -3.528 [-5.92,-1.14]
OARSI-OMERACT responder rate At week 24 76.3% 73.8%
Rescue medication paracetamol // NSAIDs % of patients who did NOT take rescue 38.8% // 92.2% 33.1% // 93.6%