Variable | Felty’s Syndrome | LGL Syndrome | Sjӧgren Syndrome | Systemic Lupus Erythematosus |
---|---|---|---|---|
Average age | 60 | 60 | 55 | 25 |
F/M ratio | 2-3/1 | 1.5/1 | 9/1 | 9/1 |
HLA | DR4 | Not known | Not known | DR2, DR3 |
CD marker | Not known | 3,8,57 | Not known | Not known |
Splenomegaly | Often | Sometimes | Rare | Not rare |
Lymphadenopathy | Not rare | Sometimes | Rare | Not rare |
Leukopenia | Neutropenia (Always) | Neutropenia (Often) | Rare | Lymphopenia (common) Neutropenia (sometimes) |
Anemia | Present ACD, AIHA | Present ACD | Present ACD | Frequent ACD, AIHA |
Autoantibody | Almost always | Sometimes | Almost always | Typical/always |
Hypocomplementemia | Frequent | Not known | Rare | Frequent |
Prognosis | Poor | Variable | Good | Variable |
Secondary malignancies | Two folds | Not known | Increased | Increased |