Table 2: The Yamagochi criteria for adult-onset Still’s disease (AOSD).

Criteria Major Criteria Minor Criteria Diagnosis
Yamaguchi et al.
(sensitivity 96.2%; specificity 92.1%)		 1. Fever≥39°C, lasting ≥1 week
2. Arthralgia, lasting ≥2 weeks
3. Typical rash
4. Leukocytosis
 (≥10,000/mm3)
including ≥80% of granulocytes		 1. Sore throat
2. Lymphadenopathy and/or splenomegaly
3. Liver dysfunction
4. Negative RF and negative
ANA		 Exclusions:
1. Infections (especially sepsis and infectious mononucleosis)
2. Malignancies (especially malignant lymphoma)
3. Rheumatic diseases (especially polyarteritis nodosa and rheumatoid vasculitis with extra-articular features)
Classification of AOSD requires: 5 or more criteria including 2 or more major criteria