Table 3: Characteristic of patients with AOSD and TD.

Ref. Sex Comorbidities Age Order of the Occurrence Laboratory Test Treatment Symptoms Prognosis
[8] F Graves’
disease
37y AOSD prior to TD Elevated FT3,
FT4, TGAb;
decreased
TSH, TMAb(+)
Cs, PTU,
propranolol, MMI
Intermittent
palpitations,
sweating,
heat intolerance,
tremor
Recovery
[9] F Basedow’s
disease
50y the diagnosis of TD prior to AOSD, but relapse concurrent AOSD decreased TSH,
elevated FT4
Cs NA Recovery
[21] F hypothyroidism 36y AOSD prior to TD decreased FT3,
FT4, TSH
Cs, MTX, Lev fatigue,
bradycardia
Recovery
[20] NA hyperthyroidism NA NA elevated T4,
decreased TSH
NA NA NA
[19] F Hyperthyroidism and
hyperthyroidism crisis
45y AOSD parallel to TD elevated FT3,
FT4;
decreased TSH
Cs, PTU, ISA irritable Recovery

F: female, AOSD: adult-onset Still’s disease, TD: thyroid disease, FT3: free tri-iodothyronine, FT4: free thyroxine, T4: thyroxine, TSH: thyroid-stimulating hormone, TGAb: antithyroglobulin antibody, TMAb: antimicrosomal antibody, Cs: corticosteroids, PTU: propylthiouracil, MMI: methimazole, MTX: methotrexate, Lev: levothyroxine, ISA: immunosuppressive agents, NA: not available.