Table 1: Summary of associations between inflammatory rheumatic diseases and MICA

Disease	MICA Variant	Population or Ethnicity	Case/Control or Family	Association (Risk or Protective)	References
RA	MICA-­-A6	Spanish	54 families and 211 cases	yes (protective)	[28]
RA	MICA-­-A6	Caucasian	90/85	yes (protective)	[29]
RA	MICA-­-A6	French Caucasian (FC) and German Caucasian (GC)	100 families (FC) and 90/182 (GC)	none	[30]
RA	MICA-­-129	French Caucasian (FC) and German Caucasian (GC)	100 families (FC) and 90/182 (GC)	yes (unknown)	[30]
AS	MICA-­-A4	Caucasian	48/50	yes (risk)	[32]
AS	MICA-­-A4	Caucasian	162/103	none due to LD with HLA-­-B27	[33]
AS	MICA-­-A4	Sardinia	82/139	yes (risk)	[34]
AS	MICA-­-129 met/met	Algerian	129/760	yes (risk)	[35]
AS	MICA*007:01	US Caucasian	1070/1003	yes (risk)	[36]
AS	MICA*007:01	Chinese Han	473/536	yes (risk)	[36]
AS	MICA*019	Chinese Han	473/536	yes (risk)	[36]
PsA	MICA-­-A9	Spanish	65/177	yes (risk)	[37]
PsA	MICA-­-A9	Spanish	110/110	yes (risk)	[38]
PsA	MICA-­-A9	Jewish	52/73	yes (risk)	[39]
PsA	MICA-­-A9	Chinese	102/210	none	[40, 41]
PsA	MICA-­-A9	mixed populations with meta-­-analysis	2002 /1933	yes (risk)	[42]
PsA	MICA-­-129-­-met/met	Canadian Caucasian	745/547	yes (risk)	[44]
psoriasis	MICA-­-A9	mixed populations with meta-­-analysis	2003 /1933	yes (risk)	[42]
psoriasis	MICA-­-A9	Chinese	105/160	none	[40]
psoriasis	MICA-­-A9	European	9247/13589	none	[46]
SLE	MICA-­-A5	Italian	48/158	yes (risk)	[47]
SLE	MICA-­-A5.1	Italian	48/158	yes (risk)	[47]
SLE	MICA-­-A9	Italian	48/158	yes (protective)	[47]
SLE	MICA-­-A5.1	Czech	123/96	yes (risk)	[48]
SLE	MICA129Met;A9	Japanese	716/351	yes (risk)	[50]
SLE	any of MICA variants	Spanish	333/361	none	[51]
BD	MICA-­-A6	Japanese	77/103	yes (risk)	[54]
BD	MICA-­-A6	Greek	38/40	yes (risk)	[55]
BD	MICA-­-A6	Korean	108/204	yes (risk)	[56]
jBD	MICA-­-A6	Italian	18/20	yes (risk)	[57]
BD	MICA-­-A6	Iranian	84/87	none due to LD with HLA-­-B51	[58]
BD	MICA-­-A6	Spanish	58/194	none due to LD with HLA-­-B51	[61]
BD	MICA-­-A6	Italian	69/130	none due to LD with HLA-­-B51	[62]
BD	MICA*009	European Caucasian	56/90	yes (risk)	[66]
BD	MICA*019	Spanish	42/165	yes (risk)	[67]
CD	MICA-­-A5.1	Tunisian	36/123	yes (protective)	[81]
CD	MICA-­-A5	Tunisian	36/123	late age of onset	[81]
CD	any of MICA variants	Caucasian	94/154	none	[90, 91]
CD	any of MICA variants	Caucasian	248/354	none	[90, 91]
UC	MICA-­-A5.1	Spanish	121/116	yes (protective)	[82]
UC	MICA-­-A5.1	Chinese	86/172 and 124/172	yes (risk)	[86, 87]
UC	MICA-­-A5	Spanish	121/116	worse progression	[82]
UC	MICA-­-A6	Tunisian	36/12	yes (risk)	[81]
UC	MICA-­-A6	Japanese	64/236	none due to LD with HLA-­-B52	[89]
UC	MICA-­-A7	Japanese	83/132	yes (risk)	[83]
UC	MICA-­-129-­-val	Chinese	272/560	yes (risk)	[88]
UC	MICA*007	European Caucasian	141/118	yes (risk)	[85]
UC	any of MICA variants	Caucasian	94/154	none	[90, 91]
UC	any of MICA variants	Caucasian	329/354	none	[90, 91]
IBD	MICA-­-129met/met	Murcians	88/154	yes (risk)	[84]