Table 4.: Treatment Responses of Cells and Markers in Sputum

Smokers Non-Smokers
Budesonide (n= 15 ) Budesonide + Formoterol (n= 14 ) p Budesonide (n= 14 ) Budesonide + Formoterol (n= 14 ) p
Cells in Sputum
Total cells (x 106/g) 1.8 (0.4-20.0) 2.5 (0.4-11.6) 0.74 2.5 (0.6-14.4) 3.1 (0.2-31.0) 0.45
Eosinophils (x 106/g) % 0 (0-0.5)
2.3 (0-16.2)
0 (0-0.1)
0.6 (0-5.3)
0.63
0.16
0 (0-0.4)
0.8 (0-8.0)
0 (0-1.1)
1.6 (0-4.0)
0.43
0.56
Neutrophils (x 106/g) % 0.7 (0.1-18.7)
29.0 (8.0-93.3)
1.0 (0-10.4)
51.5 (4.5-90.3)
0.45
0.52
0.3 (0-6.9)
14.8 (2.5-76)
1.2 (0-16.2)
29.9 (11-85)
0.01
0.12
Macrophages (x 106/g) % 1.2 (0.2-2.9)
63.3 (4.5-83.3)
1.5 (0.4-2.0)
44.8 (8.3-88.0)
0.50
0.61
1.5 (0.4-7.0)
81.0 (15.3-94.0)
1.7 (0.2-25.9)
64.5 (12.5-86.5)
0.37
0.23
Lymphocytes (x 106/g) % 0 (0-0.1)
1.3 (0-4.5)
0 (0-0.1)
0.6 (0-3.0)
0.85
0.30
0 (0-0.3)
1.4 (0-7.3)
0.1 (0-0.2)
1.8 (0-2.8)
0.65
0.74
ECP (ng/ml) 41 (19- 459) 54 (7-3851) 0.74 122 (5-370)
n=8
158 (40-1462)
n=8
0.52
MPO (ng/ml) 187 (7-997) 163 (11-7674) 0.58 103 (3-856)
n=8
36 (4-3879)
n=9
0.49

Data are median (range).