Table 1: Comparison of General Data Between the Two Periods

1990-1997 (n =748) 2003-2005 (n=311) p Value

Age (Median; range) 67 (32-91) 68 (33-95) ns

Sex
 Male 703 (94%) 279 (89.7%) p 0.014
 Female 45 (6%) 32 (10.3%)

Histology
 Squamous cell Ca 384 (51.3%) 101 (32.5%) p<0.001
 Adenocarcinoma 232 (31%) 159 (51.1%) p<0.001
 L. Cell/Undifferentiated 106 (14.2%) 41 (13.2%) ns
 Unknown 26 (3.5%) 10 (3.2%) ns

Differentiation
 Grade I 16 (2.1%) 9 (2.9%) ns
 Grade II 116 (15.5%) 38 (12.2%) ns
 Grade III 233 (31.1%) 135 (43.4%) p<0.001
 Unknown 383 (51.2%) 129(41.5%) p 0.004

Stage
 Ia 43 (5.7%) 31 (10%) ns
 Ib 70 (9.4%) 21 (6.8%)
 IIa 0 8 (2.6%)
 IIb 42 (5.6%) 18 (5.8%)
 IIIa 44 (5.9%) 28 (9%)
 IIIb 155 (20.7%) 86 (27.7%)
 IV 276 (36.9%) 116 (37.3%)
 Unknown 118 (15.8%) 3 (1%)

Treatment
 Supportive care 332 (44.4%) 73 (23.5%) p<0.001
 Surgery 167 (22.3%) 63 (20.2%) ns
 Chemotherapy 235 (31.4%) 186 (59.8%) p<0.001
 Radiotherapy 151 (20.2%) 120 (38.7%) p<0.001